INT29170

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 16.36
Pain Relevance 13.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
hippocampus 5
Macrophages 4
paw 4
cortex 3
smooth muscle 2
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 37 100.00 Very High Very High Very High
Hippocampus 18 100.00 Very High Very High Very High
allodynia 9 100.00 Very High Very High Very High
Spinal cord 8 100.00 Very High Very High Very High
cINOD 7 100.00 Very High Very High Very High
dexamethasone 1 100.00 Very High Very High Very High
chemokine 1 100.00 Very High Very High Very High
Morphine 15 99.98 Very High Very High Very High
aspirin 11 99.98 Very High Very High Very High
Hyperalgesia 20 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 19 100.00 Very High Very High Very High
Anxiety Disorder 2 100.00 Very High Very High Very High
Hyperalgesia 24 99.96 Very High Very High Very High
INFLAMMATION 57 99.90 Very High Very High Very High
Adult Respiratory Distress Syndrome 20 99.80 Very High Very High Very High
Cancer Pain 5 99.80 Very High Very High Very High
Experimental Autoimmune Neuritis 18 99.74 Very High Very High Very High
Ulcers 13 99.46 Very High Very High Very High
Pain 14 99.32 Very High Very High Very High
Lung Injury 9 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic exposure to morphine attenuates expression of interleukin-1 beta in the rat hippocampus.
Negative_regulation (attenuates) of Gene_expression (expression) of interleukin-1 beta in hippocampus associated with hippocampus and morphine
1) Confidence 0.59 Published 1996 Journal Brain Res. Section Title Doc Link 8814911 Disease Relevance 0 Pain Relevance 0.74
Attenuation of IL-1 beta expression in the hippocampus by chronic exposure to morphine may be one of the mechanisms underlying the neuro-endocrine-immune modulatory effects of opiate addiction.
Negative_regulation (Attenuation) of Gene_expression (expression) of IL-1 beta in hippocampus associated with addiction, opiate, hippocampus and morphine
2) Confidence 0.59 Published 1996 Journal Brain Res. Section Abstract Doc Link 8814911 Disease Relevance 0.09 Pain Relevance 0.80
On the other hand, a 3-day administration [4 microg/rat/day, intrathecally (i.t.)] of 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB203580), an inhibitor of p38MAPK, could suppress tactile allodynia and spontaneous pain of the bone cancer pain rats and decrease the phosphorylation of p38 as well as the expression of IL-1beta and TNF-alpha.
Negative_regulation (decrease) of Gene_expression (expression) of IL-1beta associated with pain, brush evoked pain, cancer pain and spontaneous pain
3) Confidence 0.57 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.30 Pain Relevance 1.08
At this dosage, the expressions of c-Fos, TNF-alpha, and IL-1beta in the spinal cord were significantly inhibited.
Negative_regulation (inhibited) of Gene_expression (expressions) of IL-1beta in spinal cord associated with spinal cord
4) Confidence 0.57 Published 2008 Journal J. Microbiol. Biotechnol. Section Abstract Doc Link 18955812 Disease Relevance 0.83 Pain Relevance 0.75
Pentoxifylline administration resulted in a dose-dependent reduction of the production of proinflammatory cytokines like TNFalpha, IL-1beta and IL-6, and enhancement of IL-10.
Negative_regulation (reduction) of Gene_expression (production) of IL-1beta associated with cytokine
5) Confidence 0.57 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17140731 Disease Relevance 0.52 Pain Relevance 0.78
Pre-treatment with 7-(hydroxyimino) cyclopropa[b] chromen-1a-carboxylate ethyl ester (CPCCOEt) or 2-methyl-6-(phenylethynyl)-pyridine hydrochloride (MPEP), a mGluR1 or mGluR5 antagonist, blocked IL-1beta-induced mechanical allodynia and mirror-image mechanical allodynia produced by a subcutaneous injection of 10 pg of IL-1beta.
Negative_regulation (blocked) of Gene_expression (produced) of IL-1beta-induced associated with allodynia and antagonist
6) Confidence 0.43 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 17030435 Disease Relevance 0.59 Pain Relevance 0.78
IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h.
Negative_regulation (decayed) of Gene_expression (expression) of IL-1beta in cortex associated with hippocampus
7) Confidence 0.41 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16824509 Disease Relevance 0.49 Pain Relevance 0.29
Ghrelin attenuated mechanical hyperalgesia, reduced spinal TNF-alpha and IL-1beta levels and enhanced sciatic nerve injury with correlated morphometric recovery.
Negative_regulation (reduced) of Gene_expression (levels) of IL-1beta in spinal associated with hyperalgesia, nervous system injury and sciatic nerve
8) Confidence 0.41 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20561937 Disease Relevance 1.05 Pain Relevance 1.13
One mM amygdalin significantly inhibited the expression of TNF-alpha and IL-1beta mRNAs in LPS-treated RAW 264.7 cells.
Negative_regulation (inhibited) of Gene_expression (expression) of IL-1beta in RAW 264
9) Confidence 0.41 Published 2008 Journal J. Microbiol. Biotechnol. Section Abstract Doc Link 18955812 Disease Relevance 0.77 Pain Relevance 0.46
Chronically stressed rats also exhibited anxiety-like behaviors, enhanced fecal pellet excretion, and small but significant increases in the mast cell numbers and the expression of IL-1beta and IFN-gamma.
Negative_regulation (exhibited) of Gene_expression (expression) of IL-1beta in mast cell associated with anxiety disorder
10) Confidence 0.41 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15746211 Disease Relevance 1.68 Pain Relevance 0.26
Zinc treatment (20 nmole) significantly reduced sensitivity in the early phase of the inflammation and diminished the increase in the levels of IL-1 beta and NGF without affecting paw swelling.
Negative_regulation (diminished) of Gene_expression (levels) of IL-1 beta in paw associated with pressure and volume under development, nerve growth factor and inflammation
11) Confidence 0.41 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8887968 Disease Relevance 0.77 Pain Relevance 0.84
The i.p. injection of rhIL-1 beta (10 ng/kg and 100 ng/kg) reduced the paw-withdrawal latency without affecting the colonic temperature.
Negative_regulation (reduced) of Gene_expression (injection) of rhIL-1 beta in paw associated with withdrawal
12) Confidence 0.40 Published 1996 Journal Brain Res. Section Abstract Doc Link 8930329 Disease Relevance 0.65 Pain Relevance 0.51
Administration of insulin reversed the delay in ulcer healing and significantly decreased the expression of IL-1 beta and TNF-alpha, while producing the rise in the expression of VEGF and PECAM.
Negative_regulation (decreased) of Gene_expression (expression) of IL-1 beta associated with ulcers
13) Confidence 0.29 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642793 Disease Relevance 1.55 Pain Relevance 0.11
Chronic exposure to morphine, but not ethanol, attenuates the expression of interleukin-1 beta converting enzyme in rat spleen.
Negative_regulation (attenuates) of Gene_expression (expression) of interleukin-1 beta in spleen associated with morphine
14) Confidence 0.27 Published 1997 Journal Immunol. Lett. Section Title Doc Link 9293396 Disease Relevance 0 Pain Relevance 0.40
In murine peritoneal macrophages, IL-13 administered 2 hours before stimulation with LPS, inhibited the production of IL-1 beta (- 67%) and PGE(2) (- 56%).
Negative_regulation (inhibited) of Gene_expression (production) of IL-1 beta in peritoneal macrophages
15) Confidence 0.19 Published 2001 Journal Eur. Cytokine Netw. Section Abstract Doc Link 11399514 Disease Relevance 0.66 Pain Relevance 0.58
These data suggest that IL-13, released by lymphocytes, limits inflammatory hyperalgesia by the inhibition of the production TNF-alpha, IL-1 beta, IL-8 and PGs.
Negative_regulation (inhibition) of Gene_expression (production) of IL-1 beta in lymphocytes associated with hyperalgesia and inflammation
16) Confidence 0.19 Published 2001 Journal Eur. Cytokine Netw. Section Abstract Doc Link 11399514 Disease Relevance 0.59 Pain Relevance 0.58
Macrophages from Linomide-treated EAN rats showed decreased IL-1 beta, TNF-alpha and IL-6 mRNA expression in response to IFN-gamma and LPS.
Negative_regulation (decreased) of Gene_expression (expression) of IL-1 beta in Macrophages associated with neuritis
17) Confidence 0.16 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9184648 Disease Relevance 0.97 Pain Relevance 0.76
Linomide strongly suppressed IFN-gamma and lipopolysaccharide (LPS)-induced IL-1 beta, TNF-alpha and IL-6 mRNA expression in macrophages in vitro as demonstrated by in situ hybridisation.
Negative_regulation (suppressed) of Gene_expression (expression) of IL-1 beta in macrophages
18) Confidence 0.16 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9184648 Disease Relevance 0.97 Pain Relevance 0.71
IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h.
Negative_regulation (decayed) of in hippocampus Gene_expression (expression) of IL-1beta in cortex associated with hippocampus
19) Confidence 0.14 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16824509 Disease Relevance 0.49 Pain Relevance 0.29
To confirm the degree of lung injury in this early-phase model of ALI [26], we measured mRNA expression of interleukin-1-beta (IL-1?)
Negative_regulation (measured) of Gene_expression (expression) of interleukin-1-beta in lung associated with lung injury and adult respiratory distress syndrome
20) Confidence 0.11 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.35 Pain Relevance 0.05

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