INT291751

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ALDOA, PON1) cytoskeletal protein binding (ALDOA) cytosol (ALDOA)
extracellular space (PON1) small molecule metabolic process (ALDOA) lyase activity (ALDOA)
ALDOA (Homo sapiens)
PON1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 4 77.48 Quite High
Bioavailability 8 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Coronary Artery Disease 4 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alda-1 stimulated the esterase activities of both enzymes in the absence of NAD and potentiated the effect of the coenzyme, in particular its effect on ALDH2*2.
Alda-1 Positive_regulation (stimulated) of esterase
1) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0
Thus, Alda-1 may restore the active site conformation, resulting in increased NAD binding affinity and, as a consequence, increased dehydrogenase and esterase activities.
Alda-1 Positive_regulation (increased) of esterase
2) Confidence 0.00 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.04

General Comments

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