INT291769

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.48
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ALDH2) small molecule metabolic process (ALDH2) oxidoreductase activity (ALDH2)
carbohydrate metabolic process (ALDH2)
ALDH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 187 92.04 High High
addiction 4 84.08 Quite High
headache 2 69.68 Quite High
Glutamate 4 23.76 Low Low
depression 6 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 22 99.92 Very High Very High Very High
Parkinson's Disease 4 99.44 Very High Very High Very High
Apoptosis 6 98.82 Very High Very High Very High
Toxicity 8 98.32 Very High Very High Very High
Alcohol Addiction 48 95.36 Very High Very High Very High
Disease 26 92.88 High High
Heart Rate Under Development 4 70.24 Quite High
Headache 2 69.68 Quite High
Vomiting 2 69.28 Quite High
Increased Venous Pressure Under Development 12 67.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of ALDH2 was found to be cardioprotective against acute ethanol-induced cardiac toxicity, possibly through inhibition of protein phosphatases.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ALDH2 associated with cv unclassified under development
1) Confidence 0.69 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 1.14 Pain Relevance 0.30
Our data further revealed that enhanced activation of Akt and AMPK, and subsequently, inhibition of Foxo3, apoptosis, and mitochondrial dysfunction may play a pivotal role in ALDH2 overexpression-induced cardioprotection against ethanol toxicity [130].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ALDH2 associated with parkinson's disease, toxicity and apoptosis
2) Confidence 0.49 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 1.34 Pain Relevance 0.35
As shown in Fig. 2A, GTN caused biphasic activation of sGC in the presence of both ALDH2 variants with apparent EC50 values of 3.4 ± 0.20 and 15 ± 1.5 ?
Positive_regulation (presence) of Gene_expression (variants) of ALDH2
3) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0

General Comments

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