INT291770

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.49
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (ALDOA) cytosol (ALDOA) small molecule metabolic process (ALDOA)
lyase activity (ALDOA) extracellular region (ALDOA) carbohydrate metabolic process (ALDOA)
Anatomy Link Frequency
heart 2
ALDOA (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 20 84.96 Quite High
Potency 12 48.00 Quite Low
agonist 4 31.60 Quite Low
tolerance 37 5.00 Very Low Very Low Very Low
alcohol 23 5.00 Very Low Very Low Very Low
Angina 15 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 25 98.92 Very High Very High Very High
Cv Unclassified Under Development 30 98.84 Very High Very High Very High
Reperfusion Injury 6 98.44 Very High Very High Very High
Apoptosis 8 93.40 High High
Myocardial Infarction 22 84.12 Quite High
Stress 46 82.32 Quite High
Ischemic Heart Disease 6 22.92 Low Low
Toxicity 18 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 16 5.00 Very Low Very Low Very Low
Cardiovascular Disease 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
m (panel B) GTN in the absence and presence of NAD (1 mm) or Alda-1 (10 ?
Neg (absence) Gene_expression (absence) of Alda-1
1) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0
To obtain information on the effects of the nicotinamide and, in particular, Alda-1 on bioactivation of a pharmacologically relevant GTN concentration, the same set of experiments was performed with 1 ?
Gene_expression (obtain) of Alda-1
2) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.04
Effects of Alda-1 on Ester Hydrolysis
Gene_expression (Effects) of Alda-1
3) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0
Effects of Alda-1 on GTN Denitration
Gene_expression (Effects) of Alda-1
4) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0
Effects of Alda-1 on Aldehyde Oxidation
Gene_expression (Effects) of Alda-1
5) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0
PKC knockout mice, direct activation of mitochondrial ALDH2 by an Alda-1 analogue, Alda-44, protects the heart against ischaemia/reperfusion injuries similar to what was achieved by ethanol preconditioning in the wild-type mice.66 These results indicate that ALDH2 is a direct downstream substrate of ?
Gene_expression (analogue) of Alda-1 in heart associated with targeted disruption, reperfusion injury and cv unclassified under development
6) Confidence 0.04 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.74 Pain Relevance 0
PKC knockout mice, direct activation of mitochondrial ALDH2 by an Alda-1 analogue, Alda-44, protects the heart against ischaemia/reperfusion injuries similar to what was achieved by ethanol preconditioning in the wild-type mice.66 These results indicate that ALDH2 is a direct downstream substrate of ?
Gene_expression (analogue) of Alda-44 in heart associated with targeted disruption, reperfusion injury and cv unclassified under development
7) Confidence 0.04 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.74 Pain Relevance 0

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