INT291773

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (SGCB) cytoskeleton organization (SGCB) cytoplasm (SGCB)
SGCB (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 12 99.90 Very High Very High Very High
Glutamate 6 89.16 High High
Potency 6 84.76 Quite High
tolerance 9 32.04 Quite Low
Angina 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Coronary Artery Disease 6 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of NAD, the E268Q mutant exhibited similar rates of GTN denitration as the wild type enzyme, but surprisingly generation of superoxide occurring in the course of GTN denitration was reduced, resulting in increased NO bioavailability and enhanced sGC activation in the absence of SOD.
Positive_regulation (enhanced) of Positive_regulation (activation) of sGC associated with bioavailability
1) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.16
Upon short term incubation (1 min), ALDH2*1 caused approximately half-maximal sGC activation in the presence of 1 ?
Positive_regulation (caused) of Positive_regulation (activation) of sGC
2) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.05
Alda-1 caused slight inhibition of GTN denitration and did not increase GTN-induced sGC activation in the presence of either variant.
Positive_regulation (induced) of Positive_regulation (activation) of sGC
3) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.04

General Comments

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