INT291781

Context Info Confidence 0.11 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.04

mitochondrion (ALDH2) small molecule metabolic process (ALDH2) GTPase activity (Gnat3) carbohydrate metabolic process (ALDH2) cytoplasm (Gnat3) signal transducer activity (Gnat3)

ALDH2 (Homo sapiens) Gnat3 (Mus musculus)

Pain Link Frequency Relevance Heat Potency 2 79.88 Bioavailability 4 5.00 tolerance 3 5.00 Glutamate 2 5.00 Angina 1 5.00 ischemia 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 2 5.00 Coronary Artery Disease 2 5.00 Targeted Disruption 1 5.00 Angina 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The present results indicate that Alda-1 stimulates established ALDH2 activities by improving NAD binding but does not improve the GTN binding affinity of the Asian variant.

Regulation (affinity) of ALDH2 Binding (binding) of GTN

1) Confidence 0.11 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.04

General Comments

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