INT291782

Context Info Confidence 0.12 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0 Pain Relevance 0.04

mitochondrion (ALDH2) small molecule metabolic process (ALDH2) GTPase activity (Gnat3) carbohydrate metabolic process (ALDH2) cytoplasm (Gnat3) signal transducer activity (Gnat3)

ALDH2 (Homo sapiens) Gnat3 (Mus musculus)

Pain Link Frequency Relevance Heat Potency 8 79.88 Bioavailability 16 19.52 tolerance 12 5.00 Glutamate 8 5.00 Angina 4 5.00 ischemia 4 5.00 alcohol 4 5.00

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 8 5.00 Coronary Artery Disease 8 5.00 Targeted Disruption 4 5.00 Angina 4 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

In addition, the apparent GTN affinity of ALDH2*2 was ?

ALDH2 Binding (affinity) of GTN

1) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0

This may reflect low affinity of ALDH2*2 for GTN rather than for NAD, because GTN reductase activity is only moderately increased by the coenzyme (Fig. 5).

ALDH2 Binding (affinity) of GTN

2) Confidence 0.11 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0

The present results indicate that Alda-1 stimulates established ALDH2 activities by improving NAD binding but does not improve the GTN binding affinity of the Asian variant.

ALDH2 Binding (binding) of GTN

3) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.04

Bioactivation of GTN was assayed by coincubation of ALDH2 with purified sGC and determination of GTN-induced cGMP formation.

ALDH2 Spec (determination) Binding (coincubation) of GTN

4) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0

General Comments

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