INT291784

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.30 Pain Relevance 0

cell differentiation (SERPINE2) GTPase activity (Gnat3) cytoplasm (Gnat3) signal transducer activity (Gnat3) cytosol (SERPINE2) extracellular space (SERPINE2)

SERPINE2 (Homo sapiens) Gnat3 (Mus musculus)

Pain Link Frequency Relevance Heat Bioavailability 8 5.00 tolerance 6 5.00 Glutamate 4 5.00 Potency 4 5.00 Angina 2 5.00 ischemia 2 5.00 alcohol 2 5.00

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 4 91.00 Targeted Disruption 2 56.56 Coronary Artery Disease 4 5.00 Angina 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The mechanism of GTN metabolism resulting in NO formation is still elusive, but mitochondrial aldehyde dehydrogenase (ALDH2) has been identified as key enzyme catalyzing GTN bioconversion to 1,2-GDN and inorganic nitrite (4, 5).

1,2-GDN Binding (bioconversion) of GTN

1) Confidence 0.00 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0.15 Pain Relevance 0

The mechanism of GTN metabolism resulting in NO formation is still elusive, but mitochondrial aldehyde dehydrogenase (ALDH2) has been identified as key enzyme catalyzing GTN bioconversion to 1,2-GDN and inorganic nitrite (4, 5).

1,2-GDN Binding (bioconversion) of GTN

2) Confidence 0.00 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0.15 Pain Relevance 0

General Comments

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