INT291788

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.52 Pain Relevance 0.18

small molecule metabolic process (ALDOA) lyase activity (ALDOA) GTPase activity (Gnat3) carbohydrate metabolic process (ALDOA) cytoplasm (Gnat3) signal transducer activity (Gnat3)

ALDOA (Homo sapiens) Gnat3 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 14 89.48 Potency 3 88.00 Angina 6 51.56 alcohol 10 29.60 Bioavailability 4 5.00 Glutamate 3 5.00 agonist 2 5.00 Dopamine 2 5.00 fibrosis 1 5.00 noradrenaline 1 5.00

Disease Link Frequency Relevance Heat Disease 3 84.72 Increased Venous Pressure Under Development 5 79.64 Targeted Disruption 11 70.48 Cardiovascular Disease 7 66.16 Cv General 3 Under Development 5 51.56 Myocardial Infarction 11 30.48 Toxicity 9 27.60 Stress 23 14.72 Cv Unclassified Under Development 15 5.00 Heart Disease 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Alda-1 caused slight inhibition of GTN denitration and did not increase GTN-induced sGC activation in the presence of either variant.

Alda-1 Neg (not) Positive_regulation (increase) of GTN

1) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.04

Since Alda-1 activates both the dehydrogenase activity and esterase activity of ALDH2,9,68 Beretta et al. evaluated the effect of Alda-1 on bioactivation of nitroglyercin.69 Surprisingly, Alda-1 failed to increase GTN denitration and bioactivation in these assays using either the ALDH2 wild-type and ALDH2*2 recombinant enzyme in vitro.

Alda-1 Neg (failed) Positive_regulation (increase) of GTN

2) Confidence 0.01 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.52 Pain Relevance 0.14

General Comments

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