INT291791

Context Info Confidence 0.15 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0

mitochondrion (ALDH2) small molecule metabolic process (ALDH2) GTPase activity (Gnat3) carbohydrate metabolic process (ALDH2) cytoplasm (Gnat3) signal transducer activity (Gnat3)

ALDH2 (Homo sapiens) Gnat3 (Mus musculus)

Pain Link Frequency Relevance Heat alcohol 1 43.84 tolerance 3 43.20 Glutamate 2 27.36 Bioavailability 4 5.00 Potency 2 5.00 Angina 1 5.00 ischemia 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 1 62.24 Increased Venous Pressure Under Development 2 30.20 Coronary Artery Disease 2 5.00 Angina 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Because inorganic nitrite could be excluded as intermediate, NO formation appears to result from direct enzymatic three-electron reduction of GTN by ALDH2.

ALDH2 Negative_regulation (reduction) of GTN

1) Confidence 0.15 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0.06 Pain Relevance 0

General Comments

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