INT291956

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.54
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 92.32 High High
cytokine 15 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 7 97.96 Very High Very High Very High
INFLAMMATION 11 92.32 High High
Apoptosis 5 60.20 Quite High
Glioblastoma 3 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Adenocarcinoma 1 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the precise molecular details whereby activation of the UPR results in transcriptional downregulation of iNOS have yet to be uncovered, we propose that both pathways could compete for common transcription factors or coactivators, resulting in the observed transcriptional attenuation.
Positive_regulation (activation) of Negative_regulation (downregulation) of iNOS
1) Confidence 0.41 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.54 Pain Relevance 0.08

General Comments

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