INT291961

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Context Info
Confidence 0.30
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.65
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 154 99.28 Very High Very High Very High
Thermal hyperalgesia 14 97.32 Very High Very High Very High
Inflammation 40 94.76 High High
midbrain 4 86.80 High High
nMDA receptor 22 83.56 Quite High
antagonist 18 73.68 Quite High
Analgesic 14 68.64 Quite High
IPN 26 64.88 Quite High
withdrawal 10 52.64 Quite High
Pain 34 37.08 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 154 99.28 Very High Very High Very High
Hyperalgesia 18 97.32 Very High Very High Very High
INFLAMMATION 42 94.76 High High
Injury 34 92.32 High High
Inflammatory Pain 26 64.88 Quite High
Nociception 18 55.60 Quite High
Pressure And Volume Under Development 6 46.16 Quite Low
Pain 42 37.08 Quite Low
Targeted Disruption 2 24.48 Low Low
Neuropathic Pain 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As illustrated in Fig. 1 and Fig. 2, administration of Hyp reversed up-regulation of NR2B receptors in the PAG of CFA-injected rats, it is reasonable to predict Hyp inhibiting the thermal hyperalgesia induced by chronic inflammation.
Negative_regulation (reversed) of Regulation (regulation) of NR2B associated with inflammation, thermal hyperalgesia and central grey
1) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.72 Pain Relevance 0.51
Administration of Hyp (100 mg/kg, i.g. twice daily for 3 days) reversed up-regulation of NR2B subunit in the LPAG of CFA-injected mice.


Negative_regulation (reversed) of Regulation (regulation) of NR2B
2) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.93 Pain Relevance 0.58

General Comments

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