INT291964

Context Info Confidence 0.08 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.39 Pain Relevance 1.04

transport (Grin2b) peptidase activity (Phex) Golgi apparatus (Phex) endoplasmic reticulum (Phex) plasma membrane (Grin2b) embryo development (Grin2b)

Phex (Mus musculus) Grin2b (Mus musculus)

Pain Link Frequency Relevance Heat Central grey 77 100.00 Analgesic 7 98.04 Inflammation 20 97.48 Thermal hyperalgesia 7 89.76 Pain 17 82.12 substance P 1 55.04 bradykinin 1 54.00 Serotonin 1 52.80 nMDA receptor 11 50.00 Hyperalgesia 1 38.48

Disease Link Frequency Relevance Heat Urological Neuroanatomy 77 100.00 Injury 17 100.00 INFLAMMATION 21 97.48 Hyperalgesia 9 89.76 Pain 21 82.12 Pressure And Volume Under Development 3 76.72 Nociception 9 22.44 Inflammatory Pain 13 5.00 Neuropathic Pain 4 5.00 Myelodysplastic Syndromes 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present study, we found Hyp significantly reversed the up-regulated NR2B receptors in the PAG from mice with peripheral injury, whereas it did not affect the NR2B receptor expression in the normal physiological conditions.

Hyp Neg (not) Regulation (affect) of Gene_expression (expression) of NR2B associated with injury and central grey

1) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.39 Pain Relevance 1.04

General Comments

This test has worked.