INT291968

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Context Info
Confidence 0.73
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.21
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (CA1) Golgi apparatus (CA1) cytoplasm (CA1)
Anatomy Link Frequency
neurons 2
synovial fluid 1
CA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 51 99.86 Very High Very High Very High
spinal inflammation 86 99.68 Very High Very High Very High
rheumatoid arthritis 38 99.40 Very High Very High Very High
ischemia 37 97.52 Very High Very High Very High
Osteoarthritis 36 95.84 Very High Very High Very High
nMDA receptor 6 90.48 High High
Calcium channel 1 85.52 High High
Pyramidal cell 9 71.76 Quite High
Glutamate receptor 6 59.28 Quite High
Action potential 8 57.28 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 85 99.68 Very High Very High Very High
Rheumatoid Arthritis 41 99.40 Very High Very High Very High
Cv Unclassified Under Development 36 97.52 Very High Very High Very High
Stress 429 97.24 Very High Very High Very High
Disease 126 96.16 Very High Very High Very High
Frailty 38 95.84 Very High Very High Very High
Shock 71 95.48 Very High Very High Very High
Death 39 84.48 Quite High
Parkinson's Disease 30 83.76 Quite High
Aging 48 62.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vm and that nifedipine eliminates the Cai2+ decrease at the sites of positive ?
Localization (decrease) of Cai
1) Confidence 0.73 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2803603 Disease Relevance 0.51 Pain Relevance 0.07
The CA1 in the synovial fluid may be secreted by the AS synovial membranes.
Localization (secreted) of CA1 in synovial fluid associated with spinal inflammation
2) Confidence 0.67 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.74 Pain Relevance 0.97
Currently available evidence shows that mitochondria isolated from CA1 neurons release more ROS than those from CA3 neurons (Mattiasson et al., 2003a).
Localization (release) of CA1 in neurons
3) Confidence 0.48 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.52 Pain Relevance 0
In another study, real-time monitoring of glutamate release from ischemic hippocampal slices also showed more glutamate being released from CA1 than CA3 neurons, with CA1 neurons being more susceptible to ischemia (Uchino et al., 2001).
Localization (released) of CA1 in neurons associated with glutamate and ischemia
4) Confidence 0.47 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.63 Pain Relevance 0.55
Mitochondria isolated from the CA1 release more ROS than those from the CA3 region (Mattiasson et al., 2003a).
Localization (release) of CA1
5) Confidence 0.42 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.81 Pain Relevance 0

General Comments

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