INT291968

Context Info Confidence 0.73 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 4.21 Pain Relevance 1.60

lyase activity (CA1) Golgi apparatus (CA1) cytoplasm (CA1)

Anatomy Link Frequency neurons 2 synovial fluid 1 CA1 (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate 51 99.86 spinal inflammation 86 99.68 rheumatoid arthritis 38 99.40 ischemia 37 97.52 Osteoarthritis 36 95.84 nMDA receptor 6 90.48 Calcium channel 1 85.52 Pyramidal cell 9 71.76 Glutamate receptor 6 59.28 Action potential 8 57.28

Disease Link Frequency Relevance Heat Low Back Pain 85 99.68 Rheumatoid Arthritis 41 99.40 Cv Unclassified Under Development 36 97.52 Stress 429 97.24 Disease 126 96.16 Frailty 38 95.84 Shock 71 95.48 Death 39 84.48 Parkinson's Disease 30 83.76 Aging 48 62.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Vm and that nifedipine eliminates the Cai2+ decrease at the sites of positive ?

Localization (decrease) of Cai

1) Confidence 0.73 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2803603 Disease Relevance 0.51 Pain Relevance 0.07

The CA1 in the synovial fluid may be secreted by the AS synovial membranes.

Localization (secreted) of CA1 in synovial fluid associated with spinal inflammation

2) Confidence 0.67 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.74 Pain Relevance 0.97

Currently available evidence shows that mitochondria isolated from CA1 neurons release more ROS than those from CA3 neurons (Mattiasson et al., 2003a).

Localization (release) of CA1 in neurons

3) Confidence 0.48 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.52 Pain Relevance 0

In another study, real-time monitoring of glutamate release from ischemic hippocampal slices also showed more glutamate being released from CA1 than CA3 neurons, with CA1 neurons being more susceptible to ischemia (Uchino et al., 2001).

Localization (released) of CA1 in neurons associated with glutamate and ischemia

4) Confidence 0.47 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.63 Pain Relevance 0.55

Mitochondria isolated from the CA1 release more ROS than those from the CA3 region (Mattiasson et al., 2003a).

Localization (release) of CA1

5) Confidence 0.42 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.81 Pain Relevance 0

General Comments

This test has worked.