INT2920

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Context Info
Confidence 0.45
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.90
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F8) oxidoreductase activity (F8) extracellular region (F8)
cell adhesion (F8)
Anatomy Link Frequency
plasma 1
ankles 1
F8 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 99.40 Very High Very High Very High
Calcium channel 1 97.50 Very High Very High Very High
Paracetamol 4 87.20 High High
anesthesia 4 84.88 Quite High
Codeine 1 81.12 Quite High
Pain 1 80.56 Quite High
palliative 1 75.68 Quite High
antagonist 8 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemangiosarcoma 6 99.50 Very High Very High Very High
Arthropathy 2 98.84 Very High Very High Very High
Thrombotic Thrombocytopenic Purpura 4 94.72 High High
Acute Liver Failure 8 91.20 High High
Pressure Volume 2 Under Development 1 90.08 High High
Sarcoma 1 89.80 High High
Thrombocytopenia 1 88.20 High High
Hemolytic Anemia 1 87.36 High High
Cancer 3 86.08 High High
Malignant Neoplastic Disease 3 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results imply that there are fundamental differences in the regulation of plasma fVIII levels between humans and mice.
Regulation (regulation) of fVIII in plasma
1) Confidence 0.45 Published 2003 Journal Blood Section Abstract Doc Link 12730105 Disease Relevance 0.69 Pain Relevance 0.32
A prospective double blind controlled study of three different dose regimes of Factor VIII in the treatment of haemarthroses of the knees, elbows and ankles has shown that site and severity affect the initial response and should dictate the dose.
Regulation (controlled) of Factor VIII in ankles
2) Confidence 0.38 Published 1990 Journal Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. Section Abstract Doc Link 1714851 Disease Relevance 0.25 Pain Relevance 0.08
The objective of this study was to monitor the changes in factor VIII:C associated with sequential HES and DDAVP administration.
Regulation (changes) of factor VIII
3) Confidence 0.23 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8831325 Disease Relevance 0.09 Pain Relevance 0.08
Consequently, in hemophilic mice lacking the putative inhibitory activity (i.e. overgrowth checkpoint) mediated by Factor VIII, the size of the pig implants is likely to be larger, while mouse implants growing to their expected [mouse] size will not be subject to Factor VIII control.


Regulation (control) of Factor VIII
4) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0 Pain Relevance 0
Cd(2+) (10 microM), an unspecific blocker of voltage-activated calcium channels, also antagonized FV and FVIII-induced effects, whereas the Na(+) channel blocker tetrodotoxin (10nM) did not significantly affect FV and FVIII responses.
Neg (not) Regulation (affect) of FVIII associated with tetrodotoxin and calcium channel
5) Confidence 0.18 Published 2002 Journal Toxicon Section Abstract Doc Link 12175615 Disease Relevance 0 Pain Relevance 0.15
Effects of dextran 70 on factor VIII activity.
Regulation (Effects) of factor VIII
6) Confidence 0.16 Published 1979 Journal Am J Hosp Pharm Section Title Doc Link 569441 Disease Relevance 0.54 Pain Relevance 0.08
AS were characteristically positive for vascular markers such as CD31, CD34, and factor VIII.
Regulation (positive) of factor VIII associated with hemangiosarcoma
7) Confidence 0.02 Published 2010 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 20413272 Disease Relevance 1.32 Pain Relevance 0.08

General Comments

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