INT292027

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Context Info
Confidence 0.72
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.73
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LIPE) extracellular space (LIPE) small molecule metabolic process (LIPE)
lipid particle (LIPE) plasma membrane (LIPE) lipid metabolic process (LIPE)
Anatomy Link Frequency
fat 1
adipocyte 1
LIPE (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 42 82.72 Quite High
Catecholamine 18 81.48 Quite High
anesthesia 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 462 90.20 High High
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of correlation between protein expression and mRNA level suggests that HSL may be regulated at some post-transcriptional levels (such as phosphorylation which activates HSL activity and induces HSL translocation from the cytosol to the lipid droplet upon adipocyte stimulation [3]).
Localization (translocation) of HSL in adipocyte
1) Confidence 0.72 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.63 Pain Relevance 0.04
According to our data, around 60% of HSL proteins were localized in the non-lipid fraction in the resting state.


Localization (localized) of HSL
2) Confidence 0.63 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.60 Pain Relevance 0.10
We estimated that 55 to 65% of the HSL proteins were localized in the fat-free homogenates in both depots in the resting state (figure 4).
Localization (localized) of HSL in fat
3) Confidence 0.63 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.50 Pain Relevance 0.04

General Comments

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