INT292049

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Context Info
Confidence 0.59
First Reported 2009
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 45
Disease Relevance 28.22
Pain Relevance 19.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Csnk1a1) cytoplasm (Csnk1a1) mitosis (Csnk1a1)
chromosome (Csnk1a1) nucleus (Csnk1a1) cytoskeleton (Csnk1a1)
Anatomy Link Frequency
spinal nerve 2
spinal cord 2
neurons 2
primary sensory neurons 2
peripheral nervous system 1
Csnk1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 1440 100.00 Very High Very High Very High
Neuropathic pain 1665 99.68 Very High Very High Very High
Peripheral nervous system 45 99.36 Very High Very High Very High
Spinal cord 1530 99.28 Very High Very High Very High
spinal dorsal horn 360 98.96 Very High Very High Very High
Dorsal horn neuron 135 98.64 Very High Very High Very High
Dorsal horn 765 98.56 Very High Very High Very High
primary afferent fibers 135 98.48 Very High Very High Very High
Calcitonin gene-related peptide 675 98.28 Very High Very High Very High
Glutamate receptor 360 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1440 100.00 Very High Very High Very High
Nervous System Injury 720 99.74 Very High Very High Very High
Injury 1260 99.72 Very High Very High Very High
Neuropathic Pain 2205 99.68 Very High Very High Very High
Apoptosis 90 97.60 Very High Very High Very High
Congenital Anomalies 90 82.48 Quite High
Pain 315 81.68 Quite High
Hyperalgesia 270 80.84 Quite High
Spinal Injuries 45 78.84 Quite High
Nociception 90 47.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of CK1?
Gene_expression (expression) of CK1
1) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.52 Pain Relevance 0.52
Because enhanced protein expression of CK1?
Gene_expression (expression) of CK1
2) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.84
From this preliminary comparative cDNA microarray analysis, we found that the spinal nerve injury down-regulated the expression of casein kinase 1 epsilon (CK1?)
Gene_expression (expression) of CK1 in spinal nerve associated with nervous system injury
3) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.91 Pain Relevance 0.58
Thus further rigorous study would be necessary to clarify the role of N-type Ca2+ channel on the expression of CK1?.
Gene_expression (expression) of CK1
4) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.14
Thus, CK1 isoforms expressed in central and peripheral nervous system might display region- and individual cell-specific regulation of synaptic transmission in normal and pathological states.
Gene_expression (expressed) of CK1 in peripheral nervous system associated with peripheral nervous system
5) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.42 Pain Relevance 0.44
We next examined the expression of CK1?
Spec (examined) Gene_expression (expression) of CK1
6) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.56 Pain Relevance 0.47
is expressed in primary sensory neurons and whether the expression pattern of CK1?
Gene_expression (expression) of CK1 in primary sensory neurons
7) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.82 Pain Relevance 0.29
If the SNL injury down regulates some of the gene expression including CK1?
Gene_expression (expression) of CK1 associated with injury
8) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.44 Pain Relevance 0.28
To our knowledge, this is the first report demonstrating the alteration of the expression pattern of CK1?
Gene_expression (expression) of CK1
9) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.59 Pain Relevance 0.56
expression would be that CK1?
Gene_expression (expression) of CK1
10) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.62 Pain Relevance 0.53
Furthermore, if the activation of Cav2.2 channel induces translation of CK1?
Gene_expression (translation) of CK1
11) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.45 Pain Relevance 0.25
Furthermore intense expression of CK1?
Gene_expression (expression) of CK1
12) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.87 Pain Relevance 0.31
Double staining experiments also revealed that the CK1?
Gene_expression (revealed) of CK1
13) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.52 Pain Relevance 0.30
The proportions of CK1?
Gene_expression (proportions) of CK1
14) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.23 Pain Relevance 0.70
-positive neurons and the expression level of CK1?
Gene_expression (expression) of CK1 in neurons
15) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.79 Pain Relevance 0.24
The numbers of CK1?
Gene_expression (numbers) of CK1
16) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.23 Pain Relevance 0.14
Expression level of CK1?
Gene_expression (Expression) of CK1
17) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.89 Pain Relevance 0.23
We further characterized the distribution of CK1?
Gene_expression (distribution) of CK1
18) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.48 Pain Relevance 0.44
In Cav2.2-/- spinal cord, SNL injury, in contrast, significantly reduced the percentage of the CK1?
Gene_expression (percentage) of CK1 in spinal cord associated with injury and spinal cord
19) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.55 Pain Relevance 0.25
Similar changes of CK1?
Gene_expression (changes) of CK1
20) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.89 Pain Relevance 0.23

General Comments

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