INT292050

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.17
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
middle cerebral artery 1
striatum 1
white matter 1
Iba1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 39 89.48 High High
cytokine 3 83.44 Quite High
Inflammation 6 83.04 Quite High
Spinal cord 45 80.04 Quite High
Dorsal horn 17 79.28 Quite High
spinal dorsal horn 8 72.16 Quite High
Nerve growth factor 96 65.84 Quite High
Demyelination 2 51.80 Quite High
Sciatic nerve 4 21.96 Low Low
Peripheral nervous system 5 21.36 Low Low
Disease Link Frequency Relevance Heat
Injury 120 98.72 Very High Very High Very High
Brain Injury 94 97.76 Very High Very High Very High
Middle Cerebral Artery Infarction 9 95.96 Very High Very High Very High
Death 8 94.32 High High
Blister 2 91.44 High High
Cv Unclassified Under Development 26 89.48 High High
Targeted Disruption 2 86.56 High High
Transient Ischemic Attack 2 84.00 Quite High
INFLAMMATION 4 83.04 Quite High
Nervous System Injury 16 82.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, an up-regulation and a time-dependent increase in Rab33B was observed in ischemic striatum (primarily in the ischemic core area) and was colocalized with Iba-1 positive activated microglia.
Positive_regulation (activated) of Iba-1 in striatum
1) Confidence 0.25 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC3002892 Disease Relevance 1.07 Pain Relevance 0.37
Both GFAP and Iba 1 immunostainings were significantly enhanced on the side ipsilateral to SNL injury (Figure 2Bii, Biii, D and 2E), a finding consistent with the literature [12,13].
Positive_regulation (enhanced) of Iba 1 associated with injury
2) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.45 Pain Relevance 0.33
Long term upregulation of both IBA-1-ir and galectin-3/Mac-2-ir microglia has also been observed in the subventricular zone (SVZ) following middle cerebral artery occlusion [18].
Positive_regulation (upregulation) of IBA-1-ir in middle cerebral artery associated with middle cerebral artery infarction
3) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.73 Pain Relevance 0.14
Increase in IBA-1 immunoreactive microglia within the white matter after TBI
Positive_regulation (Increase) of IBA-1 in white matter associated with brain injury
4) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.92 Pain Relevance 0

General Comments

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