INT292051

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.52
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Cav2) mitochondrion organization (Cav2) intracellular (Cav2)
protein complex (Cav2) cytoplasm (Cav2) cytosol (Cav2)
Anatomy Link Frequency
spinal cord 2
Cav2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 170 100.00 Very High Very High Very High
Neuropathic pain 185 96.04 Very High Very High Very High
Dorsal horn 85 95.16 Very High Very High Very High
Spinal nerve ligature 10 86.16 High High
spinal dorsal horn 40 79.80 Quite High
glial activation 10 75.68 Quite High
Glutamate receptor 40 73.32 Quite High
dorsal root ganglion 160 64.48 Quite High
Dorsal horn neuron 15 55.60 Quite High
Migraine 18 50.00 Quite Low
Disease Link Frequency Relevance Heat
Injury 140 100.00 Very High Very High Very High
Neuropathic Pain 245 96.04 Very High Very High Very High
Nervous System Injury 80 66.88 Quite High
Ganglion Cysts 171 64.48 Quite High
Spinal Injuries 5 58.28 Quite High
Migraine With Aura 5 50.00 Quite Low
Apoptosis 10 35.76 Quite Low
Pain 54 5.00 Very Low Very Low Very Low
Hyperalgesia 30 5.00 Very Low Very Low Very Low
Nociception 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
besides the activation of N-type Ca2+ channel, mRNA level may not be changed in Cav2.2+/+ mice but will be reduced in Cav2.2-/- mice.
Negative_regulation (reduced) of Cav2
1) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.41 Pain Relevance 0.26
On the other hand, we also observed that the expression of ~1,300 genes out of ~10,000 genes was reduced more than 1.20-fold by L5/L6 SNL injury in the Cav2.2-/- spinal cord when compared with sham-operated Cav2.2-/- mice.
Negative_regulation (reduced) of Cav2 in spinal cord associated with injury and spinal cord
2) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.57 Pain Relevance 0.68
by the up-regulated regulatory miRNAs or other unknown mechanism, protein level will be increased in Cav2.2+/+ mice but will be decreased in Cav2.2-/- mice.
Negative_regulation (decreased) of Cav2
3) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.45 Pain Relevance 0.21
In Cav2.2-/- spinal cord, SNL injury, in contrast, significantly reduced the percentage of the CK1?
Negative_regulation (reduced) of Cav2 in spinal cord associated with injury and spinal cord
4) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.56 Pain Relevance 0.25
mRNA was not changed in Cav2.2+/+ mice (1.01-fold) but decreased by 2.81-fold in Cav2.2-/- mice 2 weeks after SNL injury.
Neg (not) Negative_regulation (decreased) of Cav2 associated with injury
5) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.52 Pain Relevance 0.49
We also observed that the larger activation of CaMKII in KI samples was due to the presence of mutated CaV2.1 channel activity, because pretreatment with ?
Negative_regulation (presence) of CaV2
6) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox