INT292057

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Context Info
Confidence 0.34
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.52
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Csnk1a1) cytoplasm (Csnk1a1) mitosis (Csnk1a1)
chromosome (Csnk1a1) nucleus (Csnk1a1) cytoskeleton (Csnk1a1)
Anatomy Link Frequency
spinal 1
Csnk1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 222 99.54 Very High Very High Very High
Spinal cord 204 99.28 Very High Very High Very High
Thermal hyperalgesia 18 99.12 Very High Very High Very High
allodynia 30 98.12 Very High Very High Very High
dorsal root ganglion 192 98.00 Very High Very High Very High
intrathecal 24 96.08 Very High Very High Very High
analgesia 6 95.92 Very High Very High Very High
Peripheral nervous system 6 92.64 High High
withdrawal 12 92.56 High High
spinal dorsal horn 48 87.08 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 294 99.54 Very High Very High Very High
Hyperalgesia 36 99.12 Very High Very High Very High
Injury 168 98.88 Very High Very High Very High
Ganglion Cysts 192 98.00 Very High Very High Very High
Nervous System Injury 96 96.32 Very High Very High Very High
Spinal Injuries 6 68.64 Quite High
Pain 42 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Congenital Anomalies 12 5.00 Very Low Very Low Very Low
Nociception 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
protein is involved in the maintenance of neuropathic pain, we next examined the effects of a CK1 inhibitor IC261 [19].
Spec (examined) Regulation (effects) of CK1 associated with neuropathic pain
1) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.69 Pain Relevance 1.02
The calcium dependent transcriptional regulation may include up-regulation of CK1?
Regulation (regulation) of CK1
2) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.52 Pain Relevance 0.39
CK1 inhibitor reduced presynaptic primary afferent fiber-evoked spinal excitatory responses
Regulation (responses) of CK1 in spinal
3) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.64 Pain Relevance 1.07
To our knowledge, this is the first report demonstrating the alteration of the expression pattern of CK1?
Regulation (alteration) of CK1
4) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.59 Pain Relevance 0.57
To investigate whether the up-regulation of CK1?
Regulation (regulation) of CK1
5) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.57 Pain Relevance 0.90
mRNA and some miRNAs regulating the translation of CK1?.
Regulation (regulating) of CK1
6) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.51 Pain Relevance 0.38

General Comments

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