INT292058

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.43
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Cav2) mitochondrion organization (Cav2) intracellular (Cav2)
protein complex (Cav2) cytoplasm (Cav2) cytosol (Cav2)
Anatomy Link Frequency
spinal cord 1
Cav2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 102 99.76 Very High Very High Very High
Calcium channel 31 99.60 Very High Very High Very High
addiction 16 97.48 Very High Very High Very High
Migraine 54 95.32 Very High Very High Very High
Pyramidal cell 30 93.60 High High
depression 21 92.72 High High
Pain 66 91.04 High High
Trigeminal ganglion neurons 15 90.16 High High
Glutamate receptor 36 89.52 High High
Glutamate 29 88.52 High High
Disease Link Frequency Relevance Heat
Injury 84 98.56 Very High Very High Very High
Epilepsy 11 95.52 Very High Very High Very High
Migraine Disorders 39 95.32 Very High Very High Very High
Depression 21 92.72 High High
Pain 78 91.04 High High
Ganglion Cysts 129 89.84 High High
Targeted Disruption 23 84.56 Quite High
Headache 9 82.16 Quite High
Neurological Disease 5 80.32 Quite High
Migraine With Aura 15 79.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, if the activation of Cav2.2 channel induces translation of CK1?
Positive_regulation (activation) of Cav2
1) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.45 Pain Relevance 0.26
by the up-regulated regulatory miRNAs or other unknown mechanism, protein level will be increased in Cav2.2+/+ mice but will be decreased in Cav2.2-/- mice.
Positive_regulation (increased) of Cav2
2) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.22
expression was significantly enhanced in the Cav2.2+/+ spinal cord 2 weeks after SNL injury.
Positive_regulation (enhanced) of Cav2 in spinal cord associated with injury and spinal cord
3) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.52 Pain Relevance 0.45
Here we show that upregulation of Cav2.3 R-type calcium channels is responsible for a component of the ADP lasting several hundred milliseconds.
Positive_regulation (upregulation) of Cav2 associated with calcium channel
4) Confidence 0.49 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.37
The voltage dependence of the medium ADP, combined with its sensitivity to low concentrations of Ni2+, suggests that the medium ADP may result from upregulation of Cav2.3 R-type calcium channels.
Positive_regulation (upregulation) of Cav2 associated with addiction and calcium channel
5) Confidence 0.49 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.21
1 protein revealed facilitated activation of CaV2.1 channels and increased Ca2+ influx as the underlying molecular mechanism [7].
Positive_regulation (activation) of CaV2
6) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 1.58 Pain Relevance 1.08
We also observed that the larger activation of CaMKII in KI samples was due to the presence of mutated CaV2.1 channel activity, because pretreatment with ?
Positive_regulation (mutated) of CaV2
7) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
This finding was associated with an increased activation of CaMKII and stronger a CaV2.1 (P/Q-type) mediated rise in intracellular Ca2+.
Positive_regulation (activation) of CaV2
8) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.38 Pain Relevance 0.30

General Comments

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