INT292059

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Cav2) mitochondrion organization (Cav2) intracellular (Cav2)
protein complex (Cav2) cytoplasm (Cav2) cytosol (Cav2)
Anatomy Link Frequency
neurons 2
oocytes 2
Cav2 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 15 96.12 Very High Very High Very High
spinal dorsal horn 8 89.20 High High
qutenza 5 86.60 High High
agonist 14 86.20 High High
imagery 5 84.40 Quite High
Pyramidal cell 15 78.12 Quite High
Potency 3 77.64 Quite High
antagonist 8 73.68 Quite High
Dorsal horn 17 73.04 Quite High
Spinal cord 34 72.24 Quite High
Disease Link Frequency Relevance Heat
Injury 28 95.68 Very High Very High Very High
Nervous System Injury 16 74.56 Quite High
Sprains And Strains 1 73.36 Quite High
Pain 26 71.52 Quite High
Neurological Disease 2 65.04 Quite High
Neuropathic Pain 49 61.88 Quite High
Targeted Disruption 10 56.24 Quite High
Ganglion Cysts 43 50.00 Quite Low
Migraine With Aura 5 50.00 Quite Low
Migraine Disorders 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, SNL-induced enhancements of GFAP- and Iba 1-IR were markedly suppressed in Cav2.2-/- mice (Figure 2Cii, 2Ciii, 2D and 2E).
Positive_regulation (enhancements) of Gene_expression (suppressed) of Cav2
1) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.51 Pain Relevance 0.33
We found that DHPG application upregulated barium currents in oocytes expressing mGluR5 and Cav2.3 but not mGluR5 and Cav3.2, suggesting subunit selective modulation of R-type, but not T-type, calcium channels by mGluR5 activation with DHPG (Figure 9C and 9D).
Positive_regulation (upregulated) of Neg (not) Gene_expression (expressing) of Cav2 in oocytes associated with calcium channel
2) Confidence 0.35 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0.18 Pain Relevance 0.13
We set out to study whether such changes in P2X3 receptor function were indeed attributable to the gain of function of R192Q-mutated CaV2.1 Ca2+ channels in trigeminal neurons.
Positive_regulation (mutated) of Gene_expression (channels) of CaV2 in neurons
3) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.20 Pain Relevance 0.45

General Comments

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