INT29206

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Context Info
Confidence 0.64
First Reported 1986
Last Reported 2000
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 7
Disease Relevance 0.96
Pain Relevance 4.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Crh, POMC) extracellular space (Crh, POMC) extracellular region (Crh, POMC)
small molecule metabolic process (POMC) cell-cell signaling (POMC) response to stress (Crh)
Anatomy Link Frequency
brain 4
corticotrophs 4
Crh (Rattus norvegicus)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 3 100.00 Very High Very High Very High
narcan 9 99.92 Very High Very High Very High
opiate 15 99.84 Very High Very High Very High
Neuropeptide 4 99.60 Very High Very High Very High
agonist 27 99.56 Very High Very High Very High
antagonist 9 99.04 Very High Very High Very High
Morphine 6 88.48 High High
cerebral cortex 4 85.52 High High
Limbic system 4 81.44 Quite High
Endogenous opioid 3 72.24 Quite High
Disease Link Frequency Relevance Heat
Stress 10 100.00 Very High Very High Very High
Natriuresis 2 93.20 High High
Infection 2 75.00 Quite High
Pressure Volume 2 Under Development 2 69.44 Quite High
Heart Rate Under Development 2 68.16 Quite High
Pain 2 43.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of CRF in the release of ACTH by opiate agonists and antagonists in rats.
CRF Regulation (role) of Localization (release) of ACTH associated with antagonist, narcan, agonist and opiate
1) Confidence 0.64 Published 1987 Journal Brain Res. Section Title Doc Link 2825911 Disease Relevance 0 Pain Relevance 1.43
We examined the role of corticotropin releasing factor (CRF) in opioid actions on ACTH release.
corticotropin releasing factor Spec (examined) Regulation (role) of Localization (release) of ACTH associated with opioid
2) Confidence 0.47 Published 1987 Journal Brain Res. Section Abstract Doc Link 2825911 Disease Relevance 0 Pain Relevance 1.34
We examined the role of corticotropin releasing factor (CRF) in opioid actions on ACTH release.
CRF Spec (examined) Regulation (role) of Localization (release) of ACTH associated with opioid
3) Confidence 0.47 Published 1987 Journal Brain Res. Section Abstract Doc Link 2825911 Disease Relevance 0 Pain Relevance 1.34
Corticotropin releasing factor (CRF) is a key hormone in the integrated response to stress, acting both as the major regulator of pituitary adrenocorticotropic hormone (ACTH) release and as a neuropeptide in the brain.
CRF Regulation (regulator) of Localization (release) of ACTH in brain associated with stress and neuropeptide
4) Confidence 0.34 Published 1986 Journal Nature Section Abstract Doc Link 3001536 Disease Relevance 0.24 Pain Relevance 0.13
Corticotropin releasing factor (CRF) is a key hormone in the integrated response to stress, acting both as the major regulator of pituitary adrenocorticotropic hormone (ACTH) release and as a neuropeptide in the brain.
CRF Regulation (regulator) of Localization (release) of adrenocorticotropic hormone in brain associated with stress and neuropeptide
5) Confidence 0.30 Published 1986 Journal Nature Section Abstract Doc Link 3001536 Disease Relevance 0.24 Pain Relevance 0.13
The release of adrenocorticotropin (ACTH) from the corticotrophs is controlled principally by vasopressin and corticotropin-releasing hormone (CRH).
CRH Regulation (controlled) of Localization (release) of adrenocorticotropin in corticotrophs
6) Confidence 0.01 Published 2000 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 11004712 Disease Relevance 0.24 Pain Relevance 0.15
The release of adrenocorticotropin (ACTH) from the corticotrophs is controlled principally by vasopressin and corticotropin-releasing hormone (CRH).
corticotropin-releasing hormone Regulation (controlled) of Localization (release) of adrenocorticotropin in corticotrophs
7) Confidence 0.01 Published 2000 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 11004712 Disease Relevance 0.24 Pain Relevance 0.15

General Comments

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