INT292060

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Context Info
Confidence 0.53
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 6.03
Pain Relevance 4.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Csnk1a1) cytoplasm (Csnk1a1) mitosis (Csnk1a1)
chromosome (Csnk1a1) nucleus (Csnk1a1) cytoskeleton (Csnk1a1)
Anatomy Link Frequency
neurons 3
spinal cord 1
Csnk1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 340 99.74 Very High Very High Very High
Dorsal horn neuron 30 98.64 Very High Very High Very High
primary afferent fibers 30 98.64 Very High Very High Very High
dorsal root ganglion 320 97.92 Very High Very High Very High
spinal dorsal horn 80 97.84 Very High Very High Very High
glial activation 20 96.96 Very High Very High Very High
Calcitonin gene-related peptide 150 94.88 High High
Neuropathic pain 370 94.64 High High
Dorsal horn 170 92.36 High High
intrathecal 40 91.84 High High
Disease Link Frequency Relevance Heat
Injury 280 99.98 Very High Very High Very High
Ganglion Cysts 320 97.92 Very High Very High Very High
Neuropathic Pain 490 94.64 High High
Spinal Injuries 10 85.24 High High
Nervous System Injury 160 81.60 Quite High
Nociception 20 49.12 Quite Low
Hyperalgesia 60 42.88 Quite Low
Pain 70 5.00 Very Low Very Low Very Low
Apoptosis 20 5.00 Very Low Very Low Very Low
Congenital Anomalies 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
was observed in DRG neurons, we have analyzed mRNA level by quantitative real-time PCR method and found that the 2.03 fold increase of CK1?
Positive_regulation (increase) of CK1 in neurons associated with dorsal root ganglion
1) Confidence 0.53 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.84
These enhanced expression and following activation of CK1?
Positive_regulation (activation) of CK1
2) Confidence 0.53 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.89 Pain Relevance 0.38
Quantitative real-time PCR analysis of C57BL/6J mice 2-3 weeks after sham or SNL operation also showed no difference of the CK1?
Neg (no) Positive_regulation (difference) of CK1
3) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.56 Pain Relevance 0.47
It would be interesting to explore the mechanism by which N-type Ca2+ channel activation induced by the SNL injury leads to enhanced CK1?
Positive_regulation (enhanced) of CK1 associated with injury
4) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.80 Pain Relevance 0.59
One plausible mechanism for the enhanced CK1?
Positive_regulation (enhanced) of CK1
5) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.62 Pain Relevance 0.53
Although the increase of CK1?
Positive_regulation (increase) of CK1
6) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.67 Pain Relevance 0.29
-positive neurons with visible nuclei were equally distributed throughout the rostrocaudal length of the DRG, were randomly selected from 3 to 4 animals in naive control, sham- and SNL-operated groups and numbers of neurons that showed distinctive CK1?
Positive_regulation (distinctive) of CK1 in neurons associated with dorsal root ganglion
7) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.26 Pain Relevance 0.13
protein revealed by the immunoblot experiments, we also tested another possibility that SNL injury increased the expression level of CK1?
Positive_regulation (increased) of CK1 associated with injury
8) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.74 Pain Relevance 0.35
-positive neurons after SNL injury would explain the upregulation of CK1?
Positive_regulation (upregulation) of CK1 in neurons associated with injury
9) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.63 Pain Relevance 0.29
-IR in the spinal cord (Figure 1D) originated from the CK1?
Positive_regulation (originated) of CK1 in spinal cord associated with spinal cord
10) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.36 Pain Relevance 0.69

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