INT292062

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 7.57
Pain Relevance 6.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Csnk1a1) cytoplasm (Csnk1a1) mitosis (Csnk1a1)
chromosome (Csnk1a1) nucleus (Csnk1a1) cytoskeleton (Csnk1a1)
Anatomy Link Frequency
spinal nerve 1
spinal 1
spinal cord 1
dorsal horn 1
Csnk1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 407 99.84 Very High Very High Very High
Spinal cord 374 99.68 Very High Very High Very High
intrathecal 44 99.68 Very High Very High Very High
Thermal hyperalgesia 33 99.12 Very High Very High Very High
Dorsal horn neuron 33 98.46 Very High Very High Very High
allodynia 55 98.12 Very High Very High Very High
dorsal root ganglion 352 97.64 Very High Very High Very High
withdrawal 22 93.52 High High
spinal dorsal horn 88 90.24 High High
analgesia 11 89.68 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 176 99.96 Very High Very High Very High
Neuropathic Pain 539 99.84 Very High Very High Very High
Injury 308 99.84 Very High Very High Very High
Hyperalgesia 66 99.12 Very High Very High Very High
Ganglion Cysts 352 97.64 Very High Very High Very High
Apoptosis 22 75.52 Quite High
Nociception 22 70.36 Quite High
Congenital Anomalies 22 60.40 Quite High
Pain 77 59.60 Quite High
Spinal Injuries 11 36.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal injection of a CK1 inhibitor attenuated neuropathic pain behaviors
Negative_regulation (inhibitor) of CK1 associated with neuropathic pain and intrathecal
1) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.56 Pain Relevance 0.87
Next, we have tested the effects of a CK1 inhibitor on neuropathic pain behaviors.
Negative_regulation (inhibitor) of CK1 associated with neuropathic pain
2) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.38 Pain Relevance 0.47
Western blot analysis of the spinal cord identified the downregulation of CK1?
Negative_regulation (downregulation) of CK1 in spinal cord associated with spinal cord
3) Confidence 0.33 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2804670 Disease Relevance 1.35 Pain Relevance 0.98
The numbers of CK1?
Negative_regulation (numbers) of CK1
4) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.23 Pain Relevance 0.14
Secondly, CK1 inhibitor is effective in blocking neuropathic pain in injured hindpaw without showing any appreciable effect on uninjured hindpaw.
Negative_regulation (inhibitor) of CK1 associated with neuropathic pain
5) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.56 Pain Relevance 0.38
Firstly, CK1 inhibitor had no effect on the excitatory responses in sham-operated mice but SNL injury turned CK1 inhibitor effective in blocking excitatory responses.
Negative_regulation (inhibitor) of CK1 associated with injury
6) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.66 Pain Relevance 0.40
Expression level of CK1?
Negative_regulation (level) of CK1
7) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.89 Pain Relevance 0.23
These results suggest that blocking the CK1?
Negative_regulation (blocking) of CK1
8) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.83 Pain Relevance 1.09
CK1 inhibitor reduced presynaptic primary afferent fiber-evoked spinal excitatory responses
Negative_regulation (inhibitor) of CK1 in spinal
9) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.64 Pain Relevance 1.06
protein was indeed up-regulated in the ipsilateral superficial dorsal horn neurons of C57BL/6J mice 2 weeks after SNL injury, whereas the same injury slightly reduced the CK1?
Negative_regulation (reduced) of CK1 in dorsal horn associated with injury and dorsal horn neuron
10) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.88 Pain Relevance 0.36
After spinal nerve injury, number of CK1?
Negative_regulation (number) of CK1 in spinal nerve associated with nervous system injury
11) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.61 Pain Relevance 0.55

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox