INT292072

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Context Info
Confidence 0.53
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 9.76
Pain Relevance 5.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Csnk1a1) cytoplasm (Csnk1a1) mitosis (Csnk1a1)
chromosome (Csnk1a1) nucleus (Csnk1a1) cytoskeleton (Csnk1a1)
Anatomy Link Frequency
spinal nerve 2
Csnk1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 518 99.68 Very High Very High Very High
dorsal root ganglion 448 98.72 Very High Very High Very High
Dorsal horn neuron 42 98.64 Very High Very High Very High
primary afferent fibers 42 98.48 Very High Very High Very High
Calcitonin gene-related peptide 210 97.60 Very High Very High Very High
Spinal cord 476 96.24 Very High Very High Very High
spinal dorsal horn 112 82.04 Quite High
glial activation 28 81.00 Quite High
intrathecal 56 80.64 Quite High
Dorsal horn 238 79.24 Quite High
Disease Link Frequency Relevance Heat
Injury 392 99.98 Very High Very High Very High
Nervous System Injury 224 99.98 Very High Very High Very High
Neuropathic Pain 686 99.68 Very High Very High Very High
Ganglion Cysts 448 98.72 Very High Very High Very High
Hyperalgesia 84 67.28 Quite High
Spinal Injuries 14 63.60 Quite High
Apoptosis 28 63.48 Quite High
Congenital Anomalies 28 48.36 Quite Low
Pain 98 47.56 Quite Low
Nociception 28 36.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because enhanced protein expression of CK1?
Positive_regulation (enhanced) of Gene_expression (expression) of CK1
1) Confidence 0.53 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.84
expression at neuropathic pain state, we have investigated whether CK1?
Spec (investigated) Positive_regulation (investigated) of Spec (investigated) Gene_expression (investigated) of CK1 associated with neuropathic pain
2) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.86 Pain Relevance 0.32
Furthermore, if the activation of Cav2.2 channel induces translation of CK1?
Positive_regulation (induces) of Gene_expression (translation) of CK1
3) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.25
Furthermore intense expression of CK1?
Positive_regulation (intense) of Gene_expression (expression) of CK1
4) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.87 Pain Relevance 0.31
Furthermore, if the activation of Cav2.2 channel induces translation of CK1?
Positive_regulation (translation) of Gene_expression (translation) of CK1
5) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.45 Pain Relevance 0.25
The numbers of CK1?
Positive_regulation (numbers) of Gene_expression (numbers) of CK1
6) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.23 Pain Relevance 0.14
Because enhanced protein expression of CK1?
Positive_regulation (enhanced) of Gene_expression (expression) of CK1
7) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.84
If the SNL injury down regulates some of the gene expression including CK1?
Positive_regulation (including) of Gene_expression (expression) of CK1 associated with injury
8) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.44 Pain Relevance 0.28
Immunocytochemical analysis revealed that the spinal nerve injury changed the expression profiles of CK1?
Positive_regulation (changed) of Gene_expression (expression) of CK1 in spinal nerve associated with nervous system injury
9) Confidence 0.35 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2804670 Disease Relevance 1.09 Pain Relevance 0.61
protein revealed by the immunoblot experiments, we also tested another possibility that SNL injury increased the expression level of CK1?
Positive_regulation (increased) of Gene_expression (expression) of CK1 associated with injury
10) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.74 Pain Relevance 0.35
The percentages of CK1?
Positive_regulation (percentages) of Gene_expression (percentages) of CK1
11) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.84 Pain Relevance 0.27
The percentages of CK1?
Positive_regulation (percentages) of Gene_expression (percentages) of CK1
12) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.92 Pain Relevance 0.32
On the other hand, significant increases in the percentages of CK1?
Positive_regulation (percentages) of Gene_expression (percentages) of CK1
13) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.90 Pain Relevance 0.29
On the other hand, significant increases in the percentages of CK1?
Positive_regulation (increases) of Gene_expression (percentages) of CK1
14) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.91 Pain Relevance 0.30

General Comments

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