INT2921

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 53
Total Number 55
Disease Relevance 41.56
Pain Relevance 8.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F8) oxidoreductase activity (F8) extracellular region (F8)
cell adhesion (F8)
Anatomy Link Frequency
plasma 6
endothelial cells 2
fat 2
platelets 2
endothelium 1
F8 (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 27 100.00 Very High Very High Very High
cva 190 99.40 Very High Very High Very High
Angina 25 98.84 Very High Very High Very High
depression 202 97.68 Very High Very High Very High
Multiple sclerosis 80 96.88 Very High Very High Very High
chemokine 19 96.64 Very High Very High Very High
cytokine 63 95.48 Very High Very High Very High
abdominal pain 3 95.28 Very High Very High Very High
Pain 201 94.04 High High
headache 20 93.88 High High
Disease Link Frequency Relevance Heat
Coagulation Disorder 120 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 85 100.00 Very High Very High Very High
Congenital Anomalies 13 99.92 Very High Very High Very High
Hyperhomocysteinemia 1 99.88 Very High Very High Very High
Psychosis 46 99.84 Very High Very High Very High
Postthrombotic Syndrome 10 99.78 Very High Very High Very High
Stress 44 99.60 Very High Very High Very High
Syndrome 374 99.56 Very High Very High Very High
Thrombosis 270 99.40 Very High Very High Very High
Thrombophilia 32 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A subsequent magnetic resonance venography of his head revealed venous thrombosis, and other investigations revealed an elevated factor VIII level as well as a mutation at the MTHFR locus, consistent with an elevated risk for hypercoagulability.
Positive_regulation (elevated) of factor VIII in head associated with thrombophilia and thrombosis related under development
1) Confidence 0.59 Published 2009 Journal Clin Pediatr (Phila) Section Abstract Doc Link 19131586 Disease Relevance 0.69 Pain Relevance 0.25
Patient 2 did not respond to intravenous desmopressin infusion despite a 234% and a 360% increase in factor VIII clotting activity and ristocetin cofactor, respectively.
Positive_regulation (increase) of factor VIII associated with coagulation disorder
2) Confidence 0.58 Published 1990 Journal Pediatrics Section Abstract Doc Link 2371098 Disease Relevance 0.73 Pain Relevance 0.06
Patient 1 responded to intravenous desmopressin acetate at a dose of 0.3 microgram/kg with a 155% increase in factor VIII clotting activity and a 135% increase in ristocetin cofactor and cessation of her macrohematuria within 18 hours after completion of the desmopressin infusion.
Positive_regulation (increase) of factor VIII associated with coagulation disorder
3) Confidence 0.58 Published 1990 Journal Pediatrics Section Abstract Doc Link 2371098 Disease Relevance 0.73 Pain Relevance 0.08
Plasma factor VIII:C was increased.
Positive_regulation (increased) of factor VIII in Plasma
4) Confidence 0.58 Published 1987 Journal Dig. Dis. Sci. Section Abstract Doc Link 3691279 Disease Relevance 0.61 Pain Relevance 0.14
DDAVP produced an increase in factor VIII:C activity despite HES administration and should be considered a treatment option for the mild coagulopathy infrequently associated with HES administration.
Positive_regulation (increase) of factor VIII associated with coagulation disorder
5) Confidence 0.58 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8831325 Disease Relevance 0.17 Pain Relevance 0.08
The inhibitors rapidly disappeared after three sessions of plasmapheresis and her plasma factor VIII activity increased to a normal level.
Positive_regulation (increased) of factor VIII in plasma
6) Confidence 0.49 Published 1993 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8329575 Disease Relevance 0.50 Pain Relevance 0.12
Laboratory testing performed to exclude a hypercoaguable state, revealed heterozygosity for the Factor V Leiden mutation/activated protein C resistance and elevated factor VIII levels [3660 IU l(-1) (<1500)].
Positive_regulation (elevated) of factor VIII
7) Confidence 0.42 Published 2003 Journal Br J Radiol Section Abstract Doc Link 12893701 Disease Relevance 0.57 Pain Relevance 0.04
Desmopressin (DDAVP) increases circulating levels of factor VIII:C by stimulating the release of factor VIII:C from peripheral storage sites.
Positive_regulation (increases) of factor VIII
8) Confidence 0.42 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8831325 Disease Relevance 0.08 Pain Relevance 0.07
DDAVP has been shown to increase the plasma concentration of endothelial factor VIII, thus increasing coagulant activity.
Positive_regulation (increase) of factor VIII in plasma
9) Confidence 0.42 Published 1996 Journal Ann Plast Surg Section Abstract Doc Link 8937605 Disease Relevance 0.21 Pain Relevance 0
Factor VIII activity increased to 82% on day six.
Positive_regulation (increased) of Factor VIII
10) Confidence 0.41 Published 1979 Journal Am J Hosp Pharm Section Abstract Doc Link 569441 Disease Relevance 0.50 Pain Relevance 0.09
After study drug administration, factor VIII:C in Group 1 increased significantly to 135% of baseline at 30 min and 115% of baseline at 60 min while in Group 2 average factor VIII:C levels remained below baseline at 30 and 60 min.
Positive_regulation (increased) of factor VIII
11) Confidence 0.39 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8831325 Disease Relevance 0.08 Pain Relevance 0.08
FVIII levels increased in four of the six subjects studied without producing adverse events.
Positive_regulation (increased) of FVIII
12) Confidence 0.37 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.14 Pain Relevance 0
We studied the differential increase in FVIIIc and FVIII R:Ag after the intravenous infusion of 0.30 micrograms/kg DDAVP in 20 obligate hemophilia A carriers and in 20 female controls.
Positive_regulation (increase) of FVIII R associated with coagulation disorder
13) Confidence 0.36 Published 1984 Journal J. Pediatr. Section Abstract Doc Link 6425482 Disease Relevance 0.23 Pain Relevance 0
It is considered that the increased factor VIII:c activity in patients with unstable angina pectoris could be subsequent to the acute phase reaction induced by cytokines and/or by an enhanced adrenergic stimulation, although the possible presence of genetically-conditioned hyperactive factor VIII:c molecules can not be excluded.
Positive_regulation (increased) of factor VIII associated with angina, acute-phase reaction and cytokine
14) Confidence 0.32 Published 1996 Journal Rom J Intern Med Section Abstract Doc Link 8908632 Disease Relevance 0.70 Pain Relevance 0.65
Increased plasma factor VIII:c activity in patients with unstable angina pectoris.
Positive_regulation (Increased) of factor VIII in plasma associated with angina
15) Confidence 0.32 Published 1996 Journal Rom J Intern Med Section Title Doc Link 8908632 Disease Relevance 0.68 Pain Relevance 0.64
In view of these data, it seems that the election of the vector into which the FVIII gene has to be introduced is not a minor issue for haemophilia A gene therapy.
Positive_regulation (introduced) of FVIII associated with factor viii deficiency
16) Confidence 0.31 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.27 Pain Relevance 0
Furthermore, the capacity for activation of factor VIII was significantly lower after operation in the former group.
Positive_regulation (activation) of factor VIII
17) Confidence 0.23 Published 1983 Journal Br J Anaesth Section Abstract Doc Link 6409135 Disease Relevance 0.08 Pain Relevance 0.17
Coagulation analyses furthermore show an increase of the factor VIII activity and the plasminogen levels.
Positive_regulation (increase) of factor VIII
18) Confidence 0.21 Published 1980 Journal MMW Munch Med Wochenschr Section Abstract Doc Link 6767967 Disease Relevance 0.16 Pain Relevance 0.18
Although our patient is a smoker, used oral contraceptives and was found to have a heterozygote mutation at the factor V Leiden gene, the most important factor contributing to her thrombophilia is thought to be her significantly elevated factor VIII.
Positive_regulation (elevated) of factor VIII associated with thrombophilia
19) Confidence 0.21 Published 2007 Journal Eur J Vasc Endovasc Surg Section Abstract Doc Link 17669671 Disease Relevance 0.53 Pain Relevance 0.21
However, factor VIII was increased more than the value of T0 at T2 and T3 in both groups (Table 2).
Positive_regulation (increased) of factor VIII
20) Confidence 0.18 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2876854 Disease Relevance 0 Pain Relevance 0

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