INT29210

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Context Info
Confidence 0.37
First Reported 1984
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.60
Pain Relevance 7.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Terc) cellular_component (Terc)
Anatomy Link Frequency
tail skin 1
Terc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 12 99.98 Very High Very High Very High
antagonist 12 99.56 Very High Very High Very High
withdrawal 26 99.36 Very High Very High Very High
Morphine 44 99.04 Very High Very High Very High
narcan 32 97.88 Very High Very High Very High
opiate 10 97.04 Very High Very High Very High
addiction 2 89.80 High High
agonist 4 89.04 High High
Intracerebroventricular 4 88.40 High High
Opioid 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Diarrhoea 1 96.44 Very High Very High Very High
Galactorrhea 9 95.44 Very High Very High Very High
Disorders Of The Lacrimal System 2 95.40 Very High Very High Very High
Fever 1 91.40 High High
Cancer 4 84.64 Quite High
Stress 14 82.88 Quite High
Opiate Addiction 1 81.52 Quite High
Aging 2 80.08 Quite High
Sprains And Strains 29 54.60 Quite High
Stroke 1 16.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Due to the gradient limits of our MR system, it was not possible to decrease the minimum TR at the FOV needed to image rodent.
Spec (possible) Negative_regulation (decrease) of TR
1) Confidence 0.37 Published 2008 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2590601 Disease Relevance 0.14 Pain Relevance 0
Young rats showed the expected TST increase and Tr decline in response to withdrawal.
Negative_regulation (decline) of Tr associated with withdrawal
2) Confidence 0.35 Published 1994 Journal Exp. Gerontol. Section Abstract Doc Link 8187842 Disease Relevance 0.49 Pain Relevance 0.92
In addition, phentolamine, at high doses only, moderately reduced Tr, but the alpha-adrenergic antagonist failed to modify the decline in Tr associated with NAL-precipitated morphine withdrawal.
Negative_regulation (decline) of Tr associated with antagonist, withdrawal and morphine
3) Confidence 0.31 Published 1987 Journal Brain Res. Section Abstract Doc Link 2825916 Disease Relevance 0 Pain Relevance 1.54
A 5 degrees C increase in TST and a 1-2 degrees C decrease in rectal temperature (Tr) was observed following administration of a dose of naloxone HCl (NAL, 1 mg/kg, s.c.) which precipitated withdrawal in morphine-dependent rats.
Negative_regulation (decrease) of Tr associated with narcan, withdrawal and morphine
4) Confidence 0.31 Published 1987 Journal Brain Res. Section Abstract Doc Link 2825916 Disease Relevance 0 Pain Relevance 1.05
In addition, phentolamine, at high doses only, moderately reduced Tr, but the alpha-adrenergic antagonist failed to modify the decline in Tr associated with NAL-precipitated morphine withdrawal.
Negative_regulation (reduced) of Tr associated with antagonist, withdrawal and morphine
5) Confidence 0.30 Published 1987 Journal Brain Res. Section Abstract Doc Link 2825916 Disease Relevance 0 Pain Relevance 1.56
Although NAL and clonidine reduced Tr to a similar extent in morphine-dependent rats, their effects were not additive when the drugs were administered sequentially.
Negative_regulation (reduced) of Tr associated with morphine and clonidine
6) Confidence 0.30 Published 1987 Journal Brain Res. Section Abstract Doc Link 2825916 Disease Relevance 0 Pain Relevance 1.46
Naloxone-precipitated morphine withdrawal caused a prompt increase (4.9 +/- 0.76 degrees C) in tail skin temperature (TST) and a subsequent decline in Tr (-2.8 degrees C).
Negative_regulation (decline) of Tr in tail skin associated with narcan, withdrawal and morphine
7) Confidence 0.21 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6092986 Disease Relevance 0.97 Pain Relevance 0.67

General Comments

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