INT292128

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 100 99.96 Very High Very High Very High
Gastrointestinal Stromal Tumor 1 90.36 High High
Leukemia 1 89.00 High High
Disease 9 88.08 High High
Cancer 75 83.28 Quite High
Solid Tumor 8 58.80 Quite High
Apoptosis 8 23.92 Low Low
Pressure And Volume Under Development 7 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 6 5.00 Very Low Very Low Very Low
Fatigue 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are various reasons for the ineffectiveness of imatinib monotherapy in ovarian cancer: downregulation of c-kit and PDGFR may lead to induction of VEGF, inhibition of a single tyrosine kinase might be insufficient to impact downstream signaling cascades, and the molecular targets of imatinib might not be relevant in the occurrence of ovarian cancer in comparison with gastrointestinal stromal tumor or chronic myeloid leukemia where a single specific mutation or a translocation, respectively, can be responsible for the genesis of these two cancers [62].
Spec (may) Positive_regulation (lead) of Negative_regulation (downregulation) of PDGFR associated with leukemia, cancer, ovarian cancer and gastrointestinal stromal tumor
1) Confidence 0.25 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 1.08 Pain Relevance 0

General Comments

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