INT292237

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CCNT1) nucleolus (CCNT1) nucleus (CCNT1)
cell cycle (CCNT1) DNA binding (CCNT1) cell division (CCNT1)
Anatomy Link Frequency
monocytes 4
CCNT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 24 77.60 Quite High
Inflammation 8 74.40 Quite High
Central nervous system 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 282 94.84 High High
INFLAMMATION 10 74.40 Quite High
Infection 22 72.08 Quite High
Opportunistic Infections 2 69.84 Quite High
Death 6 37.48 Quite Low
Cancer 20 5.00 Very Low Very Low Very Low
Dementia 18 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Immunodeficiency 8 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tat activity has been shown to be limited in monocytes due to the lack of sufficient levels of cyclin T1, a component of P-TEFb [54].
Negative_regulation (lack) of Gene_expression (levels) of cyclin T1 in monocytes
1) Confidence 0.19 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.16 Pain Relevance 0
The presence of Tat has little effect on transcription in monocytes, as cyclin T1 expression is undetectable and other factors required for Tat activation are absent [54].
Negative_regulation (undetectable) of Gene_expression (expression) of cyclin T1 in monocytes
2) Confidence 0.19 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.42 Pain Relevance 0.11

General Comments

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