INT292258

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 27 100.00 Very High Very High Very High
Inflammation 41 99.60 Very High Very High Very High
Inflammatory mediators 14 95.20 Very High Very High Very High
calcitonin gene related peptide 16 82.96 Quite High
chemokine 11 82.12 Quite High
antagonist 18 71.52 Quite High
cytokine 21 37.80 Quite Low
qutenza 6 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 141 100.00 Very High Very High Very High
INFLAMMATION 53 99.60 Very High Very High Very High
Gastroesophageal Reflux Disease 12 96.16 Very High Very High Very High
Esophageal Disease 22 95.68 Very High Very High Very High
Hyperplasia 1 29.24 Quite Low
Infection 11 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
Dementia 9 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since cellular immune infiltrate is a prerequisite for severe inflammation and tissue damage, inhibition of IL-8, SP and PAF-induced PBL migration and activation may provide potential targets for therapy.


Negative_regulation (inhibition) of Positive_regulation (activation) of SP associated with inflammation and substance p
1) Confidence 0.05 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.59 Pain Relevance 0.65
B site(s) located immediately upstream of the Sp sites in the enhancer in HIV and SIV result in Sp-NF-?
Negative_regulation (located) of Positive_regulation (result) of Sp associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.02 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.24 Pain Relevance 0

General Comments

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