INT29227

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Context Info
Confidence 0.03
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NCOR2) small molecule metabolic process (NCOR2) nucleolus (NCOR2)
nucleus (NCOR2) DNA binding (NCOR2)
NCOR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 1 79.12 Quite High
Opioid 1 77.96 Quite High
Pain 1 39.40 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 34 74.40 Quite High
Pancreatic Cancer 69 71.96 Quite High
Weight Gain 1 40.24 Quite Low
Apoptosis 4 39.60 Quite Low
Pain 1 39.40 Quite Low
Metastasis 5 20.84 Low Low
Congenital Anomalies 3 19.20 Low Low
Disease 9 5.00 Very Low Very Low Very Low
Solid Tumor 3 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Equilibrium saturation binding experiments show that the inhibition of [3H]DTG binding to sigma receptors by DIGIT pretreatment of membranes is attributable to an irreversible reduction in the affinity (increase in Kd) of sigma receptors for DTG.
Positive_regulation (increase) of receptors Binding (affinity) of
1) Confidence 0.03 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2826177 Disease Relevance 0 Pain Relevance 0.12
Ligand binding induces dimerization of the cell-surface receptors resulting in auto-phosphorylation of the cytoplasmic domains and activation of the receptor’s tyrosine kinase (Olayioye et al 2000; Schlessinger 2000).
Positive_regulation (induces) of receptors Binding (dimerization) of
2) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.33 Pain Relevance 0

General Comments

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