INT29228

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Context Info
Confidence 0.02
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.62
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NCOR2) small molecule metabolic process (NCOR2) nucleolus (NCOR2)
nucleus (NCOR2) DNA binding (NCOR2)
Anatomy Link Frequency
spinal 2
brain 2
NCOR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
analgesia 106 99.62 Very High Very High Very High
tramadol 20 99.42 Very High Very High Very High
cINOD 13 97.28 Very High Very High Very High
Pain 83 95.94 Very High Very High Very High
Paracetamol 22 95.92 Very High Very High Very High
Opioid 66 95.44 Very High Very High Very High
diclofenac 5 95.38 Very High Very High Very High
Analgesic 41 94.82 High High
Dopamine 3 93.28 High High
pruritus 5 78.40 Quite High
Disease Link Frequency Relevance Heat
Post-operative Nausea 5 98.66 Very High Very High Very High
Pain 99 95.94 Very High Very High Very High
Exanthema 1 78.96 Quite High
Pruritus 5 78.40 Quite High
Post Operative Pain 10 60.24 Quite High
Sleep Disorders 11 54.68 Quite High
Respiratory Failure 14 33.44 Quite Low
Cough 1 19.84 Low Low
Vomiting 18 5.00 Very Low Very Low Very Low
Toxicity 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Equilibrium saturation binding experiments show that the inhibition of [3H]DTG binding to sigma receptors by DIGIT pretreatment of membranes is attributable to an irreversible reduction in the affinity (increase in Kd) of sigma receptors for DTG.
Negative_regulation (inhibition) of receptors Binding (binding) of
1) Confidence 0.02 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2826177 Disease Relevance 0 Pain Relevance 0.13
Equilibrium saturation binding experiments show that the inhibition of [3H]DTG binding to sigma receptors by DIGIT pretreatment of membranes is attributable to an irreversible reduction in the affinity (increase in Kd) of sigma receptors for DTG.
Negative_regulation (reduction) of receptors Binding (affinity) of
2) Confidence 0.02 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2826177 Disease Relevance 0 Pain Relevance 0.12
Guinea pig brain membranes treated with nanomolar doses of DIGIT followed by extensive washing exhibit a dose dependent reduction of [3H]DTG and (+)[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine [+)[3H]3-PPP) binding to sigma receptors.
Negative_regulation (reduction) of receptors Binding (binding) of in brain
3) Confidence 0.02 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2826177 Disease Relevance 0 Pain Relevance 0.14
Oral tramadol has been shown to have the same analgesic efficacy as oral diclofenac for post-tonsillectomy pain in patients 11 years and older, without the side effects of NSAIDs.29 It is important to note that the use of ondansetron to treat PONV results in the inhibition of tramadol analgesia probably due to a reduction of binding to the 5-HT3 receptors at the spinal level.30 Tramadol is currently available in a tablet form alone or in combination with acetaminophen in the USA.
Negative_regulation (reduction) of receptors Binding (binding) of in spinal associated with pain, tramadol, paracetamol, analgesic, analgesia, post-operative nausea, cinod and diclofenac
4) Confidence 0.01 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004641 Disease Relevance 0.62 Pain Relevance 2.09

General Comments

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