INT29229

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1984
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 5.75
Pain Relevance 8.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NCOR2) small molecule metabolic process (NCOR2) nucleolus (NCOR2)
nucleus (NCOR2) DNA binding (NCOR2)
Anatomy Link Frequency
Neuronal 1
SH-SY5Y 1
lymphocytes 1
villus 1
placenta 1
NCOR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 296 100.00 Very High Very High Very High
Opioid 22 100.00 Very High Very High Very High
opiate 12 100.00 Very High Very High Very High
methadone 8 100.00 Very High Very High Very High
agonist 364 99.98 Very High Very High Very High
Morphine 8 99.84 Very High Very High Very High
Enkephalin 8 99.74 Very High Very High Very High
antagonist 154 99.30 Very High Very High Very High
tolerance 13 98.82 Very High Very High Very High
antidepressant 1 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 102 97.60 Very High Very High Very High
Psychosis 3 97.44 Very High Very High Very High
Injury 9 97.32 Very High Very High Very High
Breast Cancer 73 97.20 Very High Very High Very High
Disease 48 96.88 Very High Very High Very High
Neuroblastoma 5 96.28 Very High Very High Very High
Schizophrenia 5 95.12 Very High Very High Very High
Metastasis 32 94.76 High High
Cancer 160 91.52 High High
Solid Tumor 4 90.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test this hypothesis, we analyzed the impact of NCOR2 siRNA interference on TGF?
Spec (analyzed) Regulation (impact) of NCOR2
1) Confidence 0.42 Published 2011 Journal Nucleic Acids Research Section Body Doc Link PMC3017614 Disease Relevance 0.08 Pain Relevance 0
Our data are consistent with this model: (i) the NCOR2 gene (coding for SMRT) is a transcriptional target of TGF?
Regulation (target) of NCOR2
2) Confidence 0.25 Published 2011 Journal Nucleic Acids Research Section Body Doc Link PMC3017614 Disease Relevance 0.13 Pain Relevance 0.09
Explant culture of term placental villus trophoblast was investigated for its possible use as a model system for study of the effects of chronic methadone administration on binding and functional properties of placental kappa receptors.
Regulation (effects) of receptors in villus associated with methadone
3) Confidence 0.08 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791132 Disease Relevance 0 Pain Relevance 0.64
These data suggest that the development of tolerance to opioids in human placenta starts with an apparent down regulation and change in the affinity of the receptors and may involve downstream events that transduce receptor activation into a biological response.
Regulation (regulation) of receptors in placenta associated with tolerance and opioid
4) Confidence 0.05 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791132 Disease Relevance 0 Pain Relevance 0.80
It does not antagonize the effects of other drugs that do not affect benzodiazepine receptors, such as narcotics, barbiturates, cyclic antidepressants, and ethanol.
Neg (not) Regulation (affect) of receptors associated with antidepressant
5) Confidence 0.04 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 0.68 Pain Relevance 0.20
Differential regulation of mu and delta opiate receptors by morphine, selective agonists and antagonists and differentiating agents in SH-SY5Y human neuroblastoma cells.
Regulation (regulation) of receptors in SH-SY5Y associated with neuroblastoma, antagonist, agonist, enkephalin, opiate and morphine
6) Confidence 0.04 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7932156 Disease Relevance 0.19 Pain Relevance 1.11
Neuronal nicotinic acetylcholine receptors (nAChRs) are a class of ion channels with significant potential as molecular targets for the design of drugs to treat a variety of CNS disorders.
Regulation (targets) of receptors in Neuronal
7) Confidence 0.04 Published 2000 Journal Pharm Acta Helv Section Abstract Doc Link 10812948 Disease Relevance 0.66 Pain Relevance 0.18
At concentrations up to 100 microM, tilidine and nortilidine had no agonist effect on the DOP, KOP and NOP receptors.
Neg (no) Regulation (effect) of receptors associated with agonist
8) Confidence 0.02 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15627429 Disease Relevance 0.06 Pain Relevance 0.85
In the present studies we used peripheral blood lymphocytes to study the effects of phencyclidine (PCP) on various receptors.
Regulation (effects) of receptors in lymphocytes
9) Confidence 0.02 Published 1984 Journal Biomed. Pharmacother. Section Abstract Doc Link 6098318 Disease Relevance 0.41 Pain Relevance 0.17
These selective antagonists also were studied alone for their effects on both receptors.
Regulation (effects) of receptors associated with antagonist
10) Confidence 0.02 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.15 Pain Relevance 1.00
The finding that sigma receptors are irreversibly modified by DIGIT whereas phencyclidine receptors are not affected suggests that sigma receptors are physically separate from phencyclidine receptors.
Neg (not) Regulation (affected) of receptors
11) Confidence 0.01 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2826177 Disease Relevance 0 Pain Relevance 0.11
WNT signals are context-dependently transduced to both pathways based on the expression profile of WNT, SFRP, WIF, DKK, Frizzled receptors, coreceptors, and the activity of intracellular WNT signaling regulators.
Regulation (regulators) of receptors
12) Confidence 0.01 Published 2007 Journal Clin. Cancer Res. Section Abstract Doc Link 17634527 Disease Relevance 0.15 Pain Relevance 0.08
Allosteric modulation of A1 receptors has been demonstrated not only in vitro but also in vivo in various species, including humans.
Regulation (modulation) of receptors
13) Confidence 0.00 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0.12 Pain Relevance 0.25
Fig. 7The location of amino acid residues involved in allosteric modulation of A1, A2A, and A3 receptors as displayed in a receptor homology model of the adenosine receptor (side and top view) based on the structure of the ?
Regulation (modulation) of receptors associated with adenocard
14) Confidence 0.00 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.14
Many representatives of class A receptors, among them adenosine receptors, have been shown to be allosterically regulated.
Regulation (regulated) of receptors associated with adenocard
15) Confidence 0.00 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.25
It is fair to assume that the residues studied so far only yield a fragmented view of the amino acids involved in the allosteric regulation of adenosine receptors.
Regulation (regulation) of receptors associated with adenocard
16) Confidence 0.00 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.16
Allosteric modulation of adenosine receptors

Allosteric modulators for adenosine receptors may have potential therapeutic advantage over orthosteric ligands.

Regulation (modulation) of receptors associated with adenocard
17) Confidence 0.00 Published 2008 Journal Purinergic Signal Section Title Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.27
It appeared to modulate the activity of many GPCRs, including opioid, muscarinic, adrenergic, and dopaminergic receptors [26].
Spec (appeared) Regulation (modulate) of receptors associated with opioid
18) Confidence 0.00 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.50
As adenosine receptors were among the first GPCRs found to be allosterically regulated, these receptors have often been reviewed also [6–8].
Regulation (regulated) of receptors associated with adenocard
19) Confidence 0.00 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.53
Allosteric modulation of adenosine receptors

Allosteric modulators for adenosine receptors may have potential therapeutic advantage over orthosteric ligands.

Regulation (modulation) of receptors associated with adenocard
20) Confidence 0.00 Published 2008 Journal Purinergic Signal Section Title Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox