INT292386

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 12
Disease Relevance 0.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Itpr3) transport (Itpr3) endoplasmic reticulum (Itpr3)
nucleolus (Itpr3) nucleus (Itpr3) transmembrane transport (Itpr3)
Anatomy Link Frequency
taste buds 1
Itpr3 (Mus musculus)
Lrmp (Mus musculus)
Pain Link Frequency Relevance Heat
member 8 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenoma 12 85.20 High High
Diabetes Mellitus 12 84.88 Quite High
Adhesions 12 45.16 Quite Low
Hypersensitivity 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because IP3R3 was coexpressed with Trpm5 in taste buds (Pérez et al. 2002), we predicted that Lrmp/Jaw1 may colocalize and interact with IP3R3.
IP3R3 Binding (interact) of Lrmp/Jaw1 in taste buds
1) Confidence 0.41 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
Lrmp/Jaw1 associated with IP3R3 in COS7 heterologous expression system
IP3R3 Binding (associated) of Lrmp/Jaw1
2) Confidence 0.41 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
Further investigation using mice lacking Lrmp/Jaw1 would provide insights regarding the role of Lrmp/Jaw1–IP3R3 interaction in taste tissue in vivo.
IP3R3 Binding (interaction) of Lrmp/Jaw1
3) Confidence 0.30 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0.17 Pain Relevance 0
Further investigation using mice lacking Lrmp/Jaw1 would provide insights regarding the role of Lrmp/Jaw1–IP3R3 interaction in taste tissue in vivo.
IP3R3 Binding (interaction) of Lrmp/Jaw1
4) Confidence 0.30 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0.17 Pain Relevance 0
Furthermore, we showed that Lrmp/Jaw1 may engage in direct protein–protein interaction with IP3R3.
IP3R3 Binding (engage) of Lrmp/Jaw1
5) Confidence 0.30 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
We also showed that Lrmp/Jaw1 may engage in direct protein–protein interaction with IP3R3.
IP3R3 Binding (interaction) of Lrmp/Jaw1
6) Confidence 0.30 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0.17 Pain Relevance 0
Furthermore, we showed that Lrmp/Jaw1 may engage in direct protein–protein interaction with IP3R3.
IP3R3 Binding (interaction) of Lrmp/Jaw1
7) Confidence 0.30 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
These results suggest that Lrmp/Jaw1 is associated with IP3R3 via its coiled-coil domain in the COS7 heterologous expression system.


IP3R3 Binding (associated) of Lrmp/Jaw1
8) Confidence 0.30 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
We also showed that Lrmp/Jaw1 may engage in direct protein–protein interaction with IP3R3.
IP3R3 Binding (engage) of Lrmp/Jaw1
9) Confidence 0.30 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0.17 Pain Relevance 0
These results raise the possibility that Lrmp/Jaw1 interacts with IP3R3 in taste cells and suggest an important role for Lrmp/Jaw1 in the IP3-Ca2+ signal cascade in sweet, bitter, and umami taste signal transduction.



IP3R3 Binding (interacts) of Lrmp/Jaw1
10) Confidence 0.30 Published 2010 Journal Chemical Senses Section Abstract Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
To investigate the protein–protein interaction between Lrmp/Jaw1 and IP3R3, we utilized the COS7 heterologous expression system and the FLAG epitope–tagged Lrmp/Jaw1 construct with/without a coiled-coil domain (FLAG-Lrmp/Jaw1 and FLAG-Lrmp/Jaw1?
IP3R3 Binding (interaction) of Lrmp/Jaw1
11) Confidence 0.30 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
In addition to this specific expression patterns, we found that Lrmp/Jaw1 is associated with type III IP3 receptor (IP3R3) via its coiled-coil domain in the COS7 heterologous expression system.
IP3 Binding (associated) of Lrmp/Jaw1
12) Confidence 0.26 Published 2010 Journal Chemical Senses Section Abstract Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0

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