INT292387

Context Info Confidence 0.45 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.31 Pain Relevance 0

nucleoplasm (Itpr3) transport (Itpr3) endoplasmic reticulum (Itpr3) nucleolus (Itpr3) nucleus (Itpr3) transmembrane transport (Itpr3)

Anatomy Link Frequency lymphoid systems 1 Lrmp (Mus musculus) Itpr3 (Mus musculus)

Pain Link Frequency Relevance Heat member 8 6 5.00

Disease Link Frequency Relevance Heat Adenoma 3 81.24 Diabetes Mellitus 3 79.80 Hypersensitivity 6 5.00 Adhesions 3 5.00

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Event

Anatomy

Negation

Speculation

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Our results raise the possibility that Lrmp/Jaw1 regulates the IP3-Ca2+ signal cascade not only in sweet, umami, and bitter taste–responsive cells but also in other cells such as related lymphoid systems.

Lrmp/Jaw1 Regulation (regulates) of IP3 in lymphoid systems

1) Confidence 0.45 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0

Although further experiments are needed, we consider that Lrmp/Jaw1 has an important role in sweet, bitter, and umami taste signal transduction by regulating the IP3-Ca2+ signal cascade.

Lrmp/Jaw1 Regulation (regulating) of IP3

2) Confidence 0.20 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0.15 Pain Relevance 0

These findings suggest that Lrmp/Jaw1 participates in taste signal transduction by regulating IP3R3.

Lrmp/Jaw1 Regulation (regulating) of IP3R3

3) Confidence 0.20 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0.16 Pain Relevance 0

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