INT29240

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Context Info
Confidence 0.40
First Reported 1983
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.17
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) small molecule metabolic process (POMC) intracellular (YY1)
DNA binding (YY1) cell-cell signaling (POMC) cytoplasm (POMC)
Anatomy Link Frequency
basal ganglia 1
POMC (Homo sapiens)
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 22 100.00 Very High Very High Very High
Dynorphin 3 100.00 Very High Very High Very High
Delta opioid receptors 1 100.00 Very High Very High Very High
Morphine 1 100.00 Very High Very High Very High
opioid receptor 8 99.96 Very High Very High Very High
mu opioid receptor 1 97.76 Very High Very High Very High
analgesia 1 96.32 Very High Very High Very High
Acupuncture 2 95.92 Very High Very High Very High
agonist 2 95.80 Very High Very High Very High
Pain 2 94.40 High High
Disease Link Frequency Relevance Heat
Pain 1 94.40 High High
Nociception 1 77.76 Quite High
Carcinoid 1 29.36 Quite Low
Disease 1 25.00 Low Low
Stress 1 5.00 Very Low Very Low Very Low
Convulsion 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study examines the receptor binding affinities of the POMC, ProEnk and ProDyn peptides to the cloned mu, delta and kappa receptors expressed transiently in transfected COS-1 cells.
POMC Binding (affinities) of delta
1) Confidence 0.40 Published 1995 Journal Brain Res. Section Abstract Doc Link 8624732 Disease Relevance 0 Pain Relevance 0.42
The three classes of endogenous opioids, originating from three distinct genes, are discussed: pro-opiomelanocortin, giving rise to beta-endorphin, ACTH and various MSHs; pro-enkephalin, giving methionine enkephalin and leucine enkephalin; and prodynorphin; their anatomical distribution and the main classes of receptors with which they interact, the mu-receptor, with a high affinity for met-enkephalin and beta-endorphin (as well as morphine and dynorphin A); the delta-receptor for which the primary ligand is leu-enkephalin; and the kappa-receptor which is the main target for the dynorphins.
beta-endorphin Binding (affinity) of delta associated with dynorphin, endogenous opioid, enkephalin and morphine
2) Confidence 0.38 Published 1987 Journal Anaesth Intensive Care Section Abstract Doc Link 3032015 Disease Relevance 0.08 Pain Relevance 1.01
This result thus strongly supports the assumption that the dimer structure of Met-enkephalin is a possible delta-receptor binding conformation.
Met-enkephalin Binding (conformation) of delta associated with enkephalin
3) Confidence 0.35 Published 2007 Journal J Mol Model Section Abstract Doc Link 16972066 Disease Relevance 0 Pain Relevance 0.58
The ability of biotinylated human beta-endorphin to cross-link the mu and delta opioid receptors to avidin allows application of the biotin-avidin system as a molecular probe of the opioid receptor.
beta-endorphin Binding (cross-link) of delta associated with opioid receptor and delta opioid receptors
4) Confidence 0.34 Published 1988 Journal J. Biol. Chem. Section Abstract Doc Link 2826453 Disease Relevance 0 Pain Relevance 0.27
Molecular modeling suggested that the decrease of the affinity of Met-enkephalin to delta-opioid receptor could be accounted for by the loss of a single hydrogen bond.
Met-enkephalin Binding (affinity) of delta associated with opioid receptor and enkephalin
5) Confidence 0.28 Published 2009 Journal ACS Chem. Biol. Section Abstract Doc Link 19634861 Disease Relevance 0 Pain Relevance 0.88
Met-enkephalin is likely to be an endogenous ligand for the delta-receptors, which predominate in the basal ganglia and limbic systems; such receptors may tonically inhibit the release of corticotrophin-releasing factor.
Met-enkephalin Spec (likely) Binding (ligand) of delta in basal ganglia associated with enkephalin
6) Confidence 0.15 Published 1983 Journal Clin Endocrinol Metab Section Abstract Doc Link 6303648 Disease Relevance 0.09 Pain Relevance 0.90

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