INT292401

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.76 Pain Relevance 0.05

extracellular space (VEGFA, fgf1a) extracellular region (VEGFA, fgf1a) cytoplasm (VEGFA, fgf1a) cell differentiation (fgf1a) growth (VEGFA) proteinaceous extracellular matrix (VEGFA)

Anatomy Mention Frequency VBM 1 VEGFA (Homo sapiens) fgf1a (Danio rerio)

Pain Term Frequency Confidence Heat rheumatoid arthritis 1 90.36 cINOD 1 5.00

Disease Term Frequency Confidence Heat Cancer 12 93.80 Diabetic Retinopathy 1 91.36 Rheumatoid Arthritis 1 90.36 Wound Healing 1 87.16 Solid Tumor 1 74.96 Toxicity 1 18.32 Apoptosis 4 5.00 Breast Cancer 1 5.00 Adverse Drug Reaction 1 5.00 Malignant Neoplastic Disease 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Angiogenesis involves the coordination of several steps: (i) binding of angiogenic stimulating factors [vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF)] to their receptors on endothelial cells, (ii) secretion of proteases, which degrade the vascular basement membrane (VBM) and the surrounding ECM, (iii) endothelial proliferation and migration, (iv) endothelial differentiation and tube formation, (v) reformation of the VBM, (vi) recruitment of pericytes, which surround and stabilize the newly formed vessel (4–6).

vascular endothelial growth factor Binding (binding) of fibroblast growth factor in VBM

1) Confidence 0.01 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.76 Pain Relevance 0.05

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