INT292404

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTPN1) endoplasmic reticulum (PTPN1) plasma membrane (PTPN1)
Anatomy Link Frequency
endothelial cells 2
fibroblasts 1
ovary 1
PTPN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 46.20 Quite Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 24 99.40 Very High Very High Very High
Cancer 72 75.96 Quite High
INFLAMMATION 6 45.96 Quite Low
Diabetic Retinopathy 6 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low
Solid Tumor 6 5.00 Very Low Very Low Very Low
Breast Cancer 6 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 6 5.00 Very Low Very Low Very Low
Wound Healing 6 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The specific PTP1B inhibitor used in this work has been seen to stimulate insulin signaling and Akt phosphorylation in ovary cells (35), but no references regarding effects on endothelial cells have been found.
Negative_regulation (inhibitor) of PTP1B in ovary
1) Confidence 0.25 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.19 Pain Relevance 0
The PTP1B inhibitor did not seem to have any inhibitory effect on the endothelial cells in the co-culture angiogenesis assay.
Negative_regulation (inhibitor) of PTP1B in endothelial cells
2) Confidence 0.19 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.41 Pain Relevance 0
The PTP1B inhibitor was the only tested phosphatase inhibitor which had no effect on the cells in the angiogenesis assay.
Negative_regulation (inhibitor) of PTP1B
3) Confidence 0.19 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0 Pain Relevance 0
In fibroblasts, however, PTP1B inhibition has been seen to result in a decreased cell migration (34).
Negative_regulation (inhibition) of PTP1B in fibroblasts
4) Confidence 0.18 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.25 Pain Relevance 0
A previous study suggests that inhibiting PTP1B induces a pro-angiogenic effect, i.e. a promotion of endothelial cell proliferation and migration (33).
Negative_regulation (inhibiting) of PTP1B in endothelial cell
5) Confidence 0.18 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.28 Pain Relevance 0
Clodronate disodium salt, salubrinal, Protein tyrosine phosphatase 1B (PTP1B) inhibitor, Shp1/2 inhibitor (NSC87877), PTP inhibitor I, II, and IV were from Merck (Darmstadt, Germany).
Negative_regulation (inhibitor) of PTP1B
6) Confidence 0.18 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.06 Pain Relevance 0

General Comments

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