INT292454

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.73
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BAD, BCL2) cytoplasm (BAD, BCL2) cytosol (BAD, BCL2)
cell morphogenesis (BCL2) endoplasmic reticulum (BCL2) intracellular (BCL2)
BAD (Homo sapiens)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 52 44.52 Quite Low
Inflammation 26 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 188 100.00 Very High Very High Very High
Stomach Cancer 5 95.48 Very High Very High Very High
Pancreatic Cancer 49 93.68 High High
Malignant Neoplastic Disease 3 92.52 High High
Cancer 143 91.76 High High
Lung Cancer 8 88.16 High High
Prostate Cancer 8 77.04 Quite High
Osteogenic Sarcomas 2 68.48 Quite High
Death 28 50.00 Quite Low
Leukemia 9 40.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The nonphosphorylated form of Bad plays a pro-apoptotic role, by binding Bcl-xL or Bcl-2 and, thus, preventing their interactions with Bak and Bax.
Bad Binding (binding) of Bcl-2 associated with apoptosis
1) Confidence 0.03 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.92 Pain Relevance 0
Phosphorylation prevents Bad from binding either Bcl-2 or Bcl-XL and thus suppresses apoptosis.
Bad Binding (binding) of Bcl-2 associated with apoptosis
2) Confidence 0.01 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.81 Pain Relevance 0

General Comments

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