INT292460

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GEM, PTK2) extracellular matrix organization (PTK2) embryo development (PTK2)
GTPase activity (GEM) microtubule organizing center (PTK2) cytoplasm (PTK2)
Anatomy Link Frequency
AsPC-1 2
GEM (Homo sapiens)
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 37 95.04 Very High Very High Very High
Pancreatic Cancer 48 94.52 High High
Cancer 17 5.00 Very Low Very Low Very Low
Adhesions 7 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Breast Cancer 1 5.00 Very Low Very Low Very Low
Lung Cancer 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicated that in AsPC-1 cells, LN-induced FAK phosphorylation mediated the intrinsic chemoresistance to Gem, and this effect might be related with the regulation of survivin and pBad (pS136) level

Effects of PF-228 on Gem-induced apoptosis in pancreatic cancer cells

Gem Positive_regulation (mediated) of Phosphorylation (phosphorylation) of FAK in AsPC-1 associated with pancreatic cancer and apoptosis
1) Confidence 0.20 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.52 Pain Relevance 0

General Comments

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