INT292463

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.70 Pain Relevance 0

extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2) cytoplasm (PTK2) signal transducer activity (PTK2) cytosol (PTK2)

Anatomy Link Frequency AsPC-1 2 LAMB2 (Homo sapiens) PTK2 (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 37 99.04 Pancreatic Cancer 48 80.48 Cancer 17 67.12 Adhesions 7 60.64 Metastasis 4 5.00 Malignant Neoplastic Disease 2 5.00 Death 1 5.00 Breast Cancer 1 5.00 Lung Cancer 1 5.00 Disease 1 5.00

Sentences Mentioned In

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Anatomy

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Speculation

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We further found that laminin (LN) induced FAK and Akt phosphorylation in a time-dependent manner, increased the levels of survivin and pBad (pS136) and decreased Gem-induced cytotoxicity and apoptosis in AsPC-1 cells; Specific inhibition of LN-induced FAK phosphorylation by either FAK RNAi or FRNK overexpression suppressed the effects of LN on AsPC-1 cells.

laminin Positive_regulation (induced) of Phosphorylation (phosphorylation) of FAK in AsPC-1 associated with apoptosis

1) Confidence 0.01 Published 2009 Journal Mol Cancer Section Abstract Doc Link PMC2806309 Disease Relevance 0.70 Pain Relevance 0

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