INT292474

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2)
cytoplasm (PTK2) signal transducer activity (PTK2) cytosol (PTK2)
Anatomy Link Frequency
lymph node 2
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 8 41.64 Quite Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 336 99.84 Very High Very High Very High
Cancer 214 99.08 Very High Very High Very High
Adhesions 53 98.60 Very High Very High Very High
Metastasis 58 94.84 High High
Apoptosis 259 91.60 High High
Malignant Neoplastic Disease 16 86.60 High High
Skin Cancer 20 86.40 High High
Cytomegalovirus Infection 7 80.56 Quite High
Disease 9 78.40 Quite High
Breast Cancer 7 59.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The annealed oligos in FAK RNAi1 plasmid were:
Negative_regulation (oligos) of Gene_expression (plasmid) of FAK RNAi1
1) Confidence 0.41 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.08 Pain Relevance 0
We demonstrated herein that specific RNAi against FAK reduced FAK expression, decreased FAK phosphorylation and thus suppressed the intrinsic chemoresistance to Gem in Panc-1 cells, which had a high level of pFAK (pY397).
Negative_regulation (reduced) of Gene_expression (expression) of FAK
2) Confidence 0.41 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.52 Pain Relevance 0
High FAK protein expression is also present in pancreatic cancer, but not significantly related to clinicopathological factors such as tumor histological grade, lymph node metastasis, distant metastasis, histological stage, and overall survival in pancreatic cancer patients [17].
Negative_regulation (present) of Gene_expression (expression) of FAK in lymph node associated with cancer, pancreatic cancer and metastasis
3) Confidence 0.41 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 1.49 Pain Relevance 0
The C-terminal non-catalytic domain of FAK termed FRNK functions as a competitive inhibitor of FAK and ectopic expression of FRNK specifically inhibits FAK autophosphorylation at Tyr397 and thus attenuates its activity [19,20].
Negative_regulation (inhibits) of Gene_expression (expression) of FRNK
4) Confidence 0.41 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.59 Pain Relevance 0
PF-228 is a more specific method to decrease FAK phosphorylation compared with FRNK overexpression.
Negative_regulation (decrease) of Gene_expression (overexpression) of FRNK
5) Confidence 0.41 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.41 Pain Relevance 0
The C-terminal non-catalytic domain of FAK termed FRNK functions as a competitive inhibitor of FAK and ectopic expression of FRNK specifically inhibits FAK autophosphorylation at Tyr397 and thus attenuates its activity [19,20].
Negative_regulation (inhibits) of Gene_expression (expression) of FAK
6) Confidence 0.41 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.66 Pain Relevance 0
The levels of phosphorylated FAK and Akt began to rise at 15 min and peaked at 1 h after adhesion to LN, followed by a decline over 24 h.
Negative_regulation (rise) of Gene_expression (levels) of FAK associated with adhesions
7) Confidence 0.41 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.23 Pain Relevance 0
Overall, an inverse relationship was noted between FAK and E-cadherin expression (Additional File 3: A).
Negative_regulation (noted) of Gene_expression (expression) of FAK
8) Confidence 0.18 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 1.20 Pain Relevance 0

General Comments

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