INT292483

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.51
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2)
cytoplasm (PTK2) signal transducer activity (PTK2) cytosol (PTK2)
Anatomy Link Frequency
Section 3 2
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 56 90.32 High High
cytokine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 89 99.06 Very High Very High Very High
Adhesions 159 98.80 Very High Very High Very High
Cancer 425 98.56 Very High Very High Very High
Apoptosis 121 97.88 Very High Very High Very High
Pancreatic Cancer 76 96.56 Very High Very High Very High
Skin Cancer 16 87.60 High High
Reprotox - General 3 8 79.36 Quite High
Reprotox - General 1 232 78.08 Quite High
Metastasis 176 70.04 Quite High
Shock 4 39.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous study in breast cancer cells has also found that FRNK overexpression inhibited the activation of FAK and PKB and thus enhanced chemotherapy-induced cell apoptosis [37].
Negative_regulation (inhibited) of Positive_regulation (activation) of FAK associated with breast cancer and apoptosis
1) Confidence 0.41 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.59 Pain Relevance 0
Genistein consistently inhibits FAK activation in all of these studies, irrespective of its effect upon adhesion [120, 123, 125].
Negative_regulation (inhibits) of Positive_regulation (activation) of FAK associated with adhesions
2) Confidence 0.14 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 1.36 Pain Relevance 0
Additionally, genistein inhibits FAK activation, resulting in increased cell adhesion.
Negative_regulation (inhibits) of Positive_regulation (activation) of FAK associated with adhesions
3) Confidence 0.11 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.49 Pain Relevance 0
These results imply that genistein’s effects on both cell adhesion (see Section 3.2) and cell migration are in part regulated by its ability to inhibit activation of FAK.
Negative_regulation (inhibit) of Positive_regulation (activation) of FAK in Section 3 associated with adhesions
4) Confidence 0.10 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.55 Pain Relevance 0.18
At this time, it is unclear whether the activation of Smad1 and FAK are due to genistein’s inhibition of MEK4 or via a different signaling mechanism
Spec (whether) Negative_regulation (due) of Spec (whether) Positive_regulation (activation) of FAK
5) Confidence 0.10 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.51 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox