INT2925

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Context Info
Confidence 0.70
First Reported 1978
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 16.76
Pain Relevance 6.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) aging (Mpo)
Anatomy Link Frequency
neutrophil 6
plasma 4
leukocyte 4
MPO 2
nerve 2
Mpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 7 100.00 Very High Very High Very High
Raphe magnus 12 99.96 Very High Very High Very High
dexamethasone 2 99.70 Very High Very High Very High
Nerve growth factor 51 99.62 Very High Very High Very High
Central grey 8 99.04 Very High Very High Very High
cva 46 98.48 Very High Very High Very High
Inflammation 42 97.88 Very High Very High Very High
Morphine 10 96.24 Very High Very High Very High
Thermal hyperalgesia 24 95.80 Very High Very High Very High
Inflammatory marker 4 92.44 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 94 100.00 Very High Very High Very High
Ulcers 8 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 4 100.00 Very High Very High Very High
Mononeuropathies 2 100.00 Very High Very High Very High
Sensorineural Hearing Loss 2 100.00 Very High Very High Very High
Stress 22 99.82 Very High Very High Very High
Sprains And Strains 13 99.56 Very High Very High Very High
Cancer 2 99.40 Very High Very High Very High
Necrosis 3 99.16 Very High Very High Very High
Distal Myopathy 2 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In capsaicin-treated infected rats, the MPO increase at day 12 was augmented, and MPO was still not returned to preinfection values by day 35; in contrast, the increase of mast cell numbers at days 12 and 35 was not modified by afferent nerve depletion.
Positive_regulation (augmented) of Positive_regulation (increase) of MPO in nerve
1) Confidence 0.70 Published 2000 Journal Neuroimmunomodulation Section Body Doc Link 11251391 Disease Relevance 0.06 Pain Relevance 0
Our study showed that cold-restraint stress for 3 h induced hemorrhagic lesions and increased myeloperoxidase activity in the gastric mucosa.
Positive_regulation (induced) of Positive_regulation (increased) of myeloperoxidase associated with stress
2) Confidence 0.70 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12559379 Disease Relevance 1.31 Pain Relevance 0.52
At 4 h, indomethacin increased the ulcer index (UI) and myeloperoxidase (MPO) activity in basal and histamine-stimulated states, whereas SC-560 only increased MPO activity.
Positive_regulation (increased) of Positive_regulation (increased) of MPO associated with ulcers and urological neuroanatomy
3) Confidence 0.50 Published 2010 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 20082628 Disease Relevance 0.60 Pain Relevance 0.16
It is concluded that: (1) in response to chemical stimulation of MPO, the number of I-cells that were inhibited was more than three times the number of I-cells that were excited; in contrast, the number of E-cells that were excited was more than twice the number of E-cells that were inhibited. (2) The interaction between MPO and NRM can be modulated by blockade of the neuronal transmission or blockade of the glutamatergic system in the PAG. (3) Simultaneous activity of many synapses is required for activation of the MPO-NRM pathway. (4) MPO to NRM interaction is mediated by fibers with a conduction velocity of less than 1m/s.
Positive_regulation (required) of Positive_regulation (activation) of MPO in MPO associated with raphe magnus, urological neuroanatomy and central grey
4) Confidence 0.49 Published 2001 Journal Pain Section Abstract Doc Link 11690727 Disease Relevance 0.90 Pain Relevance 0.44
Colchicine (0.3 and 1 mg/kg) attenuated the NGF (0.8 and 4 microg)-induced increase in tissue myeloperoxidase (MPO) as determined 6 h after NGF application.
Positive_regulation (-induced) of Positive_regulation (increase) of MPO associated with nerve growth factor and urological neuroanatomy
5) Confidence 0.49 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9750013 Disease Relevance 0.89 Pain Relevance 0.96
Both oxicams produced a similar extent of the gastric mucosal damage and a significant decrease in PGE2 synthesis, however only piroxicam induced an increase of both myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-alpha content in the gastric mucosa, indicating that neutrophil-derived free radicals were involved in gastric injury.
Positive_regulation (induced) of Positive_regulation (increase) of MPO in neutrophil associated with necrosis, cancer, injury and urological neuroanatomy
6) Confidence 0.47 Published 2002 Journal Free Radic. Res. Section Abstract Doc Link 12180128 Disease Relevance 0.63 Pain Relevance 0.22
Both oxicams produced a similar extent of the gastric mucosal damage and a significant decrease in PGE2 synthesis, however only piroxicam induced an increase of both myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-alpha content in the gastric mucosa, indicating that neutrophil-derived free radicals were involved in gastric injury.
Positive_regulation (induced) of Positive_regulation (increase) of myeloperoxidase in neutrophil associated with necrosis, cancer, injury and urological neuroanatomy
7) Confidence 0.47 Published 2002 Journal Free Radic. Res. Section Abstract Doc Link 12180128 Disease Relevance 0.63 Pain Relevance 0.22
RESULTS: Infection with N. brasiliensis resulted in an increase of myeloperoxidase (MPO) activity and mast cell numbers at day 12 postinfection; MPO returned to preinfection levels by day 35 while mast cell numbers remained elevated at that time.
Positive_regulation (resulted) of Positive_regulation (increase) of MPO in mast cell
8) Confidence 0.47 Published 2000 Journal Neuroimmunomodulation Section Body Doc Link 11251391 Disease Relevance 0.08 Pain Relevance 0
Administration of heparin caused a marked increase of plasma MPO.
Positive_regulation (caused) of Positive_regulation (increase) of MPO in plasma associated with urological neuroanatomy
9) Confidence 0.47 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20643239 Disease Relevance 1.06 Pain Relevance 0.09
Initial experiments showed that intradermal injection of recombinant human (rh) NGF (0.8 and 4 microg) caused a longlasting increase in tissue myeloperoxidase (MPO) indicating leukotactic activity of NGF.
Positive_regulation (caused) of Positive_regulation (increase) of MPO associated with nerve growth factor and urological neuroanatomy
10) Confidence 0.45 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9750013 Disease Relevance 0.77 Pain Relevance 0.83
A diagnosis of drug-induced ANCA-associated vasculitis (on the basis of mononeuritis multiplex, sensorineural hearing loss and markedly increased anti-myeloperoxidase (MPO) ANCA) and statin-induced distal myopathy was made.
Positive_regulation (induced) of Positive_regulation (increased) of MPO associated with distal myopathy, urological neuroanatomy, sensorineural hearing loss, mononeuropathies and increased venous pressure under development
11) Confidence 0.45 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 18839266 Disease Relevance 1.43 Pain Relevance 0.22
Neither strain showed a significant increase in bronchoalveolar chemotactic activity, myeloperoxidase activity, leukocyte infiltration, or chemokine accumulation, indicating that there was no significant pulmonary inflammation.


Positive_regulation (increase) of Positive_regulation (accumulation) of myeloperoxidase in leukocyte associated with chemokine, inflammation, pneumonia and sprains and strains
12) Confidence 0.45 Published 2010 Journal Thromb J Section Abstract Doc Link PMC2843658 Disease Relevance 1.25 Pain Relevance 0.45
In conclusion, our results demonstrate that, in addition to a systemic increase of MPO in patients presenting early with STEMI, levels of this leukocyte enzyme are increased at the culprit coronary lesion before PCI.
Positive_regulation (increased) of Positive_regulation (increase) of MPO in leukocyte associated with urological neuroanatomy
13) Confidence 0.44 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20643239 Disease Relevance 0.69 Pain Relevance 0.07
Colchicine (0.3 and 1 mg/kg) attenuated the NGF (0.8 and 4 microg)-induced increase in tissue myeloperoxidase (MPO) as determined 6 h after NGF application.
Positive_regulation (-induced) of Positive_regulation (increase) of myeloperoxidase associated with nerve growth factor and urological neuroanatomy
14) Confidence 0.42 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9750013 Disease Relevance 0.89 Pain Relevance 0.95
Hepatic MPO activity in the ANIT-treated group was significantly higher than that in the control group at 24 h after treatment and the increase in hepatic MPO activity in the ANIT-treated group was enhanced at 48 h (Fig. 4).
Positive_regulation (enhanced) of Positive_regulation (increase) of MPO associated with urological neuroanatomy
15) Confidence 0.42 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 1.14 Pain Relevance 0.13
Treatment with dexamethasone prevented the increase in colonic damage score and MPO activity elicited by intravenous hapten administration.
Positive_regulation (increase) of Positive_regulation (elicited) of MPO associated with urological neuroanatomy and dexamethasone
16) Confidence 0.41 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7631788 Disease Relevance 1.28 Pain Relevance 0.31
Treatment with dexamethasone prevented the increase in colonic damage score and MPO activity elicited by intravenous hapten administration.
Positive_regulation (elicited) of Positive_regulation (increase) of MPO associated with urological neuroanatomy and dexamethasone
17) Confidence 0.41 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7631788 Disease Relevance 1.28 Pain Relevance 0.31
A diagnosis of drug-induced ANCA-associated vasculitis (on the basis of mononeuritis multiplex, sensorineural hearing loss and markedly increased anti-myeloperoxidase (MPO) ANCA) and statin-induced distal myopathy was made.
Positive_regulation (induced) of Positive_regulation (increased) of anti-myeloperoxidase associated with distal myopathy, urological neuroanatomy, sensorineural hearing loss, mononeuropathies and increased venous pressure under development
18) Confidence 0.39 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 18839266 Disease Relevance 1.42 Pain Relevance 0.22
In the rat with acute isolation of the basal part of the suprachiasmatic area and SCH, stimulation of the MPO failed to induce ovulation and LH release, but was followed by FSH release.
Neg (failed) Positive_regulation (induce) of Positive_regulation (stimulation) of MPO in SCH associated with urological neuroanatomy
19) Confidence 0.37 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 569773 Disease Relevance 0.28 Pain Relevance 0.14
Irradiation resulted in increased myeloperoxidase activity, indicative of neutrophil infiltration, and prostaglandin E2 synthesis by 2 h post-irradiation, but had no effect on leukotriene B4 synthesis.
Positive_regulation (resulted) of Positive_regulation (increased) of myeloperoxidase in neutrophil
20) Confidence 0.34 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 7585340 Disease Relevance 0 Pain Relevance 0.06

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