INT292508

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAD) cytosol (BAD) pigmentation (Mlph)
mitochondrion (BAD) protein targeting (Mlph) cytoplasm (BAD)
Anatomy Link Frequency
AsPC-1 4
Mlph (Mus musculus)
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 111 99.92 Very High Very High Very High
Pancreatic Cancer 144 83.52 Quite High
Cancer 51 61.92 Quite High
Adhesions 21 42.76 Quite Low
Metastasis 12 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Breast Cancer 3 5.00 Very Low Very Low Very Low
Lung Cancer 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, inhibition of FAK phosphorylation by FRNK overexpression antagonized the effects of LN on survivin expression and Bad phosphorylation at Ser136 in AsPC-1 cells (Fig. 10D).
LN Regulation (effects) of Phosphorylation (phosphorylation) of Bad in AsPC-1
1) Confidence 0.01 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.45 Pain Relevance 0
LN also caused an increase in the expression of survivin and the phosphorylation of Bad at Ser136 but did not affect Bax, Bcl-2 or Bad expression or Bad phosphorylation at Ser112 in AsPC-1cells (Fig. 10D).
LN Neg (not) Regulation (affect) of Phosphorylation (phosphorylation) of Bad
2) Confidence 0.01 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.40 Pain Relevance 0
Consistent with the results of FAK RNAi and FRNK overexpression, PF-228 decreased survivin expression and Bad phosphorylation at Ser136 in Panc-1 cells and antagonized the effects of LN on survivin expression and Bad phosphorylation at Ser136 in AsPC-1 cells (Fig. 14A-B).
LN Regulation (effects) of Phosphorylation (phosphorylation) of Bad in AsPC-1
3) Confidence 0.01 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.66 Pain Relevance 0

General Comments

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