INT292563

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.73
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2RL1, TNF) signal transduction (TNF) extracellular space (TNF)
extracellular region (TNF) Golgi apparatus (F2RL1) intracellular (TNF)
F2RL1 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 30 98.20 Very High Very High Very High
antagonist 15 72.60 Quite High
agonist 39 64.56 Quite High
cytokine 12 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
IPN 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 6 98.92 Very High Very High Very High
INFLAMMATION 36 98.20 Very High Very High Very High
Cancer 6 96.20 Very High Very High Very High
Apoptosis 3 34.00 Quite Low
Stress 6 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 3 5.00 Very Low Very Low Very Low
Reperfusion Injury 3 5.00 Very Low Very Low Very Low
Inflammatory Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proteinase-activated receptor-2 mediated inhibition of TNF?
Proteinase-activated receptor-2 Negative_regulation (inhibition) of TNF
1) Confidence 0.15 Published 2010 Journal Cellular Signalling Section Title Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.07
In conclusion we have demonstrated for the first time a novel mechanism whereby PAR2, a GPCR can disrupt TNF?
PAR2 Negative_regulation (disrupt) of TNF
2) Confidence 0.15 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.37 Pain Relevance 0.09
Specific points:1.PAR2 mediated inhibition of TNF?
PAR2 Negative_regulation (inhibition) of TNF
3) Confidence 0.15 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.37 Pain Relevance 0.09

General Comments

This test has worked.

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