INT292575

Context Info Confidence 0.39 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.20 Pain Relevance 0.04

extracellular space (TNFRSF1A) extracellular region (TNFRSF1A) plasma membrane (TNFRSF1A) nucleus (TNFRSF1A) protein complex (TNFRSF1A)

TNFRSF1A (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 10 74.32 agonist 13 5.00 antagonist 5 5.00 cytokine 4 5.00 Inflammatory response 1 5.00 Inflammatory mediators 1 5.00 IPN 1 5.00 chemokine 1 5.00 Arthritis 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 12 74.32 Cancer 2 64.16 Apoptosis 1 57.48 Disease 2 41.84 Stress 2 5.00 Arthritis 1 5.00 Necrosis 1 5.00 Cv Unclassified Under Development 1 5.00 Reperfusion Injury 1 5.00 Inflammatory Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

At this point the exact mechanism mediating disruption is unclear, no studies to date have identified any PKC phosphorylation sites within the TNFR1 complex, and thus it is possible that additional intermediate proteins may be involved.

Phosphorylation (phosphorylation) of TNFR1

1) Confidence 0.39 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.20 Pain Relevance 0.04

General Comments

This test has worked.