INT292583

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNFRSF1A) extracellular region (TNFRSF1A) plasma membrane (TNFRSF1A)
nucleus (TNFRSF1A) protein complex (TNFRSF1A)
TNFRSF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 41.84 Quite Low
agonist 26 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 78.24 Quite High
INFLAMMATION 24 41.84 Quite Low
Cancer 4 31.68 Quite Low
Disease 4 9.36 Low Low
Stress 4 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Reperfusion Injury 2 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also demonstrate for the first time receptor mediated driven disruption of TNFR1 binding to a number of associated proteins.
Negative_regulation (disruption) of TNFR1 Binding (binding) of
1) Confidence 0.21 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.08 Pain Relevance 0
Two recent studies have shown the potential of PMA, a PKC activator, to disrupt TNFR1 binding to these intermediates [42,50], however the study presented here is the first to show that this can be receptor mediated.
Negative_regulation (disrupt) of TNFR1 Binding (binding) of
2) Confidence 0.21 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.07 Pain Relevance 0

General Comments

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