INT292595

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.29
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
endothelium 2
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 90 97.04 Very High Very High Very High
cytokine 14 88.52 High High
chemokine 4 84.40 Quite High
agonist 78 84.16 Quite High
antagonist 18 77.84 Quite High
Inflammatory mediators 10 49.24 Quite Low
Arthritis 12 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 44 98.14 Very High Very High Very High
INFLAMMATION 108 97.04 Very High Very High Very High
Targeted Disruption 4 86.56 High High
Breast Cancer 2 86.28 High High
Carcinoma 2 73.36 Quite High
Disease 14 64.56 Quite High
Apoptosis 2 46.28 Quite Low
Arthritis 12 5.00 Very Low Very Low Very Low
Metastasis 8 5.00 Very Low Very Low Very Low
Chronic Obstructive Pulmonary Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, p73 expression [43] can be tumor suppressive or oncogenic depending on isoforms of its gene product [44]. p73 expression was downregulated herein by PAR-2 activation, along with 8 fold increases in WWOX, suggesting that PAR-2 leads to reduced p73 transcriptional activity [43].
Negative_regulation (downregulated) of Positive_regulation (activation) of PAR-2 associated with cancer
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.74 Pain Relevance 0.06
Array data showed that the expression of a number of histone deacetylase (HDAC) genes (HDAC3, 7A, 11) was suppressed by PAR2 activation, as were the related sirtuins 2, 3, 5 and 6 (Table 6).
Negative_regulation (suppressed) of Positive_regulation (activation) of PAR2
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0 Pain Relevance 0.11
For example, in the endothelium, activation of PAR2 would be able to reduce the damaging effects of TNF?
Negative_regulation (reduce) of Positive_regulation (activation) of PAR2 in endothelium
3) Confidence 0.35 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.31 Pain Relevance 0.08
To our surprise we found that PAR2 activation was able to strongly mediate an inhibition of TNF?
Negative_regulation (able) of Positive_regulation (activation) of PAR2
4) Confidence 0.35 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.23 Pain Relevance 0.38

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox